| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Metabolic dysfunction is associated with steatosis but no other histologic features in nonalcoholic fatty liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Ning Dai, Cheng-Fu Xu, Hong-Ying Pan, Hai-Jun Huang, Mei-Juan Chen, You-Ming Li and Chao-Hui Yu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81800507 |
| the Public Welfare Project of the Science and Technology Agency, Zhejiang Province |
LGF18H030010 |
| Medical and Health Research Project of Zhejiang Province |
2018KY256 |
| Medical and Health Research Project of Zhejiang Province |
2019KY294 |
|
| Corresponding Author |
Chao-Hui Yu, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zyyyych@zju.edu.cn |
| Key Words |
Nonalcoholic fatty liver disease; Metabolic associated fatty liver disease; Liver histology; Hepatic steatosis; Fibrosis |
| Core Tip |
Non-obese and metabolically healthy patients with fatty liver are excluded from the definition of metabolic-associated fatty liver disease (MAFLD), but their clinical course has seldom been demonstrated. We analysed a group of nonalcoholic fatty liver disease (NAFLD) subjects, and found that the MAFLD subgroup had a higher NAFLD activity score and higher severity of hepatic steatosis than the non-MAFLD subgroup. There was no difference in other histologic features, including lobular and portal inflammation, balloon degeneration, and fibrosis, between the MAFLD and non-MAFLD patients. The grade of steatosis correlated positively with the hepatocellular ballooning degree, and the presence of nonalcoholic steatohepatitis. We believe that our study can provide insight into the histologic features of various subsets of fatty liver disease. |
| Publish Date |
2022-04-30 05:08 |
| Citation |
Dai YN, Xu CF, Pan HY, Huang HJ, Chen MJ, Li YM, Yu CH. Metabolic dysfunction is associated with steatosis but no other histologic features in nonalcoholic fatty liver disease. World J Clin Cases 2022; 10(13): 4097-4109 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i13/4097.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i13.4097 |
