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Articles Published Processes
12/10/2021 9:08:48 AM | Browse: 505 | Download: 851
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Received |
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2021-07-10 14:59 |
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Peer-Review Started |
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2021-07-10 15:04 |
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To Make the First Decision |
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Return for Revision |
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2021-08-19 10:20 |
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Revised |
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2021-08-19 18:16 |
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Second Decision |
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2021-11-24 03:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-11-25 01:25 |
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Articles in Press |
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2021-11-25 01:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-12-07 02:55 |
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Publish the Manuscript Online |
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2021-12-10 09:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Anatomy & Morphology |
| Manuscript Type |
Review |
| Article Title |
Enteric nervous system and inflammatory bowel diseases: Correlated impacts and therapeutic approaches through the P2X7 receptor
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Henrique Inhauser Riceti Magalhães and Patricia Castelucci |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Foundation of São Paulo |
2014/25927-2 |
| Research Foundation São Paulo |
2018/07862-1 |
| National Council for Scientific and Technological Development (CNPq) |
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| Corresponding Author |
Patricia Castelucci, MHSc, PhD, Associate Professor, Associate Research Scientist, Lecturer, Department of Anatomy, University of São Paulo, Av. Dr Lineu Prestes , 2415, São Paulo 08000-000, SP, Brazil. pcastel@usp.br |
| Key Words |
Chemical coding; Enteric nervous system; Gastroenterology; Inflammatory bowel diseases; P2X7 receptor; Purinergic signaling |
| Core Tip |
This review summarizes the impacts caused by inflammatory bowel diseases on enteric nervous system cells and brings together the findings of the most recent literature on therapeutic approaches through the P2X7 receptor. Despite the great advancement of knowledge in the field, data on the mechanisms and effects of neuronal loss during colitis are still scarce. Furthermore, clinical trials that would make the use of P2X7 receptor antagonists in human patients feasible are lacking. In the laboratory, the results of animal models reinforce that the P2X7 receptor may be an important future target for the treatment of intestinal disorders. |
| Publish Date |
2021-12-10 09:08 |
| Citation |
Magalhães HIR, Castelucci P. Enteric nervous system and inflammatory bowel diseases: Correlated impacts and therapeutic approaches through the P2X7 receptor. World J Gastroenterol 2021;27(46): 7909-7924 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i46/7909.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i46.7909 |
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