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Articles Published Processes
12/31/2021 12:21:18 PM | Browse: 749 | Download: 2045
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Received |
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2021-07-14 00:49 |
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Peer-Review Started |
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2021-07-14 00:54 |
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First Decision by Editorial Office Director |
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2021-10-03 07:06 |
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Return for Revision |
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2021-10-03 07:06 |
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Revised |
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2021-10-22 17:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-12-13 03:30 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-12-22 23:30 |
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Articles in Press |
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2021-12-22 23:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-12-29 14:52 |
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Publish the Manuscript Online |
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2021-12-31 12:21 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tao Huang, Yuan-Qing-Xiao Li, Ming-Yu Zhou, Rui-Han Hu, Gao-Liang Zou, Jian-Chao Li, Shu Feng, Yong-Mei Liu, Chang-Qin Xin and Xue-Ke Zhao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81860115 |
| National Natural Science Foundation of China (General Program) |
82060116 |
| National Natural Science Foundation of China (General Program) |
81960118 |
| Science and Technology Support Project of Guizhou Province |
No.［2021］094 |
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| Corresponding Author |
Xue-Ke Zhao, PhD, Professor, infectious diseases , affiliated hospital of guizhou medical university, 9th Beijing Road, Guiyang 550004, Guizhou Province, China. zhaoxueke1@163.com |
| Key Words |
Liver fibrosis; Hepatic stellate cells; Focal adhesion kinase; Focal adhesion kinase-related non-kinase; Aerobic glycolysis; Enolase1 |
| Core Tip |
We show that focal adhesion kinase-related non-kinase (FRNK) limits hepatic stellate cell (HSC) activation, proliferation, and migration and promotes HSC apoptosis by inhibiting aerobic glycolysis, thereby ameliorating liver fibrosis. FRNK may represent a potential therapeutic candidate for liver fibrosis treatment. |
| Publish Date |
2021-12-31 12:21 |
| Citation |
Huang T, Li YQX, Zhou MY, Hu RH, Zou GL, Li JC, Feng S, Liu YM, Xin CQ, Zhao XK. Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway. World J Gastroenterol 2022; 28(1): 123-139 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i1/123.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i1.123 |
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