Publication Name	World Journal of Gastroenterology
Manuscript ID	69979
Country	Brazil

Received	2021-07-18 19:57
Peer-Review Started	2021-07-18 20:01
To Make the First Decision
Return for Revision	2021-08-15 18:51
Revised	2021-08-21 14:33
Second Decision	2022-01-17 05:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-01-20 04:10
Articles in Press	2022-01-20 04:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-14 21:40
Typeset the Manuscript	2022-01-28 09:59
Publish the Manuscript Online	2022-02-09 07:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	COVID-19, liver dysfunction and pathophysiology: A conceptual discussion
Manuscript Source	Invited Manuscript
All Author List	Jucier Gonçalves Júnior
ORCID	Author(s) ORCID Number Jucier Gonçalves Júnior http://orcid.org/0000-0001-5077-7959
Funding Agency and Grant Number
Corresponding Author	Jucier Gonçalves Júnior, MD, PhD, Academic Research, Department of Internal Medicine, Division of Rheumathology, São Paulo University, Av. Dr. Arnaldo, 455, 3º Andar-Sala 3131 Cerqueira César, São Paulo 01246-903, State, Brazil. juciergjunior@hotmail.com
Key Words	COVID-19; Intracellular signaling peptides and proteins; Immunopathology; Liver diseases; Liver injury; SARS-CoV-2
Core Tip	This paper aimed to present new hypotheses on the pathophysiology of liver injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Interactions between SARS-CoV-2 spike protein and other membrane receptors in the liver; “gut-liver axis” disruption and dysbiosis; and increased inflammatory process mediated by interleukin-6 and AT1R-metalloprotease 17 seem to be factors that contribute to such injury.
Publish Date	2022-02-09 07:25
Citation	Gonçalves Júnior J. COVID-19, liver dysfunction and pathophysiology: A conceptual discussion. World J Gastroenterol 2022; 28(6): 683-688
URL	https://www.wjgnet.com/1007-9327/full/v28/i6/683.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i6.683

Full Article (PDF)	WJG-28-683.pdf
Full Article (Word)	WJG-28-683.docx
Manuscript File	69979_Auto_Edited-JRF-Filipodia CL.docx
Answering Reviewers	69979-Answering reviewers.pdf
Audio Core Tip	69979-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	69979-Conflict-of-interest statement.pdf
Copyright License Agreement	69979-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	69979-Language certificate.pdf
Peer-review Report	69979-Peer-review(s).pdf
Scientific Misconduct Check	69979-Bing-Fan JR-2.png
Scientific Editor Work List	69979-Scientific editor work list.pdf
CrossCheck Report	69979-CrossCheck report.pdf
CrossCheck Report	69979-CrossCheck.png