Publication Name	World Journal of Gastroenterology
Manuscript ID	7001
Country	Italy

Received	2013-10-31 15:20
Peer-Review Started	2013-10-31 20:04
To Make the First Decision	2014-02-26 15:19
Return for Revision	2014-03-13 18:27
Revised	2014-04-10 16:15
Second Decision	2014-06-05 10:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-05 11:14
Articles in Press	2014-06-05 11:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-10 09:04
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Microbiology
Manuscript Type	Topic Highlights
Article Title	Methodological issues in the study of intestinal microbiota in irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Valentina Taverniti and Simone Guglielmetti
Funding Agency and Grant Number
Corresponding Author	Simone Guglielmetti, PhD, Division of Food Microbiology and Bioprocessing, Department of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, Via Celoria 2, 20133 Milan, Italy. simone.guglielmetti@unimi.it
Key Words	Intestinal dysfunction; Irritable bowel syndrome; Intestinal microbiota; Bifidobacteria; New generation DNA sequencing
Core Tip	Irritable bowel syndrome (IBS) is the intestinal functional disorder with the highest prevalence in the industrialized world. The intestinal microbiota (IM) plays a role in its pathogenesis. Since the methodological aspects of the research on IM in IBS have never been considered in detail before, we carried out a revision of 29 original research articles. We reviewed the scientific microbiological message in light of the experimental method adopted. The analytical revision of the studies referenced in our review leaded to the identification of microbial groups whose relative abundance resulted significantly altered in IBS. Such microbial groups are potential IM signatures of IBS.
Publish Date	2014-07-21 17:17
Citation	Taverniti V, Guglielmetti S. Methodological issues in the study of intestinal microbiota in irritable bowel syndrome. World J Gastroenterol 2014; 20(27): 8821-8836
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/8821.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.8821

Full Article (PDF)	WJG-20-8821.pdf
Full Article (Word)	WJG-20-8821.doc
Manuscript File	7001-Review.docx
Answering Reviewers	7001-Answering reviewers.pdf
Copyright License Agreement	7001-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7001-Language certificate.pdf
Peer-review Report	7001-Peer reviews.pdf
Scientific Misconduct Check	7001-CrossCheck.jpg
Scientific Editor Work List	7001-Scientific editor work list.pdf