Publication Name	World Journal of Clinical Cases
Manuscript ID	70041
Country	China

Received	2021-08-10 11:21
Peer-Review Started	2021-08-10 11:25
To Make the First Decision
Return for Revision	2021-10-20 22:11
Revised	2021-10-29 10:04
Second Decision	2022-06-22 09:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-06-26 22:58
Articles in Press	2022-06-26 22:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-07 11:38
Publish the Manuscript Online	2022-07-22 07:03

ISSN	2307-8960 (online)
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Category	Hematology
Manuscript Type	Case Report
Article Title	Antibiotic and glucocorticoid-induced recapitulated hematological remission in acute myeloid leukemia: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Yun Sun, Xiao-Dong Yang, Xiao-Qiu Yang, Bo Ju, Nuan-Nuan Xiu, Jia Xu and Xi-Chen Zhao
ORCID	Author(s) ORCID Number Xiao-Yun Sun http://orcid.org/0000-0002-4667-9974 Xiao-Dong Yang http://orcid.org/0000-0001-6754-9004 Xiao-Qiu Yang http://orcid.org/0000-0002-5212-9178 Bo Ju http://orcid.org/0000-0003-1610-8481 Nuan-Nuan Xiu http://orcid.org/0000-0003-4369-0147 Jia Xu http://orcid.org/0000-0002-2444-8980 Xi-Chen Zhao http://orcid.org/0000-0002-3304-2851
Funding Agency and Grant Number	Funding Agency Grant Number Specialized Scientific Research Fund Projects of The Medical Group of Qingdao University YLJT20201002
Corresponding Author	Xi-Chen Zhao, MD, Chief Doctor, Department of Hematology, The Central Hospital of Qingdao West Coast New Area, No. 9 Huangpujiang road, Qingdao 266555, Shandong Province, China. zhaoxichen2003@163.com
Key Words	Acute myeloid leukemia; Fms-like tyrosine kinase 3 tyrosine kinase domain; Glucocorticoid; Antibiotic; Spontaneous remission; Gastrointestinal infection; Case report
Core Tip	Untreated leukemia patients usually experience an aggressive process. However, spontaneous remission occasionally occurs in a small number of patients with acute myeloid leukemia. Here, we report an acute myeloid leukemia (AML) patient with t(8;21) translocation who achieved recapitulated spontaneous remissions after antibiotic and dexamethasone treatments for febrile episodes and skin lesions. These antibiotic and dexamethasone treatment-induced spontaneous remissions indicated that inflammatory stresses, most likely arising from gastrointestinal infection, sustained the growth and survival advantage of the leukemia cells. Inflammation-sustained proliferation may represent a specific subgroup of AML.
Publish Date	2022-07-22 07:03
Citation	Sun XY, Yang XD, Yang XQ, Ju B, Xiu NN, Xu J, Zhao XC. Antibiotic and glucocorticoid-induced recapitulated hematological remission in acute myeloid leukemia: A case report and review of literature. World J Clin Cases 2022; 10(22): 7890-7898
URL	https://www.wjgnet.com/2307-8960/full/v10/i22/7890.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i22.7890

Full Article (PDF)	WJCC-10-7890.pdf
Full Article (Word)	WJCC-10-7890.docx
Manuscript File	70041_Auto_Edited-LS.docx
Answering Reviewers	70041-Answering reviewers.pdf
Audio Core Tip	70041-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	70041-Conflict-of-interest statement.pdf
Copyright License Agreement	70041-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	70041-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	70041-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	70041-Language certificate.pdf
Peer-review Report	70041-Peer-review(s).pdf
Scientific Misconduct Check	70041-Bing-Wang JJ-2.png
Scientific Editor Work List	70041-Scientific editor work list.pdf
CrossCheck Report	70041-CrossCheck report.pdf