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Articles Published Processes
6/22/2022 8:29:42 AM | Browse: 294 | Download: 885
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Received |
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2021-08-08 22:30 |
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Peer-Review Started |
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2021-08-08 22:31 |
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To Make the First Decision |
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Return for Revision |
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2021-09-02 02:11 |
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Revised |
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2021-09-16 22:31 |
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Second Decision |
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2022-05-23 03:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-05-28 07:18 |
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Articles in Press |
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2022-05-28 07:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-05-31 03:00 |
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Publish the Manuscript Online |
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2022-06-22 08:29 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Molecular docking of DS-3032B, a mouse double minute 2 enzyme antagonist with potential for oncology treatment development
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vítor Hugo Sales da Mota, Fabrício Freire de Melo, Breno Bittencourt de Brito, Filipe Antônio França da Silva and Kádima Nayara Teixeira |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kádima Nayara Teixeira, PhD, Adjunct Professor, Campus Toledo, Universidade Federal do Paraná, Road 182, km 320/321, Toledo 85.919-899, Paraná, Brazil. kadimateixeira@ufpr.br |
| Key Words |
DS-3032B; Mouse double minute 2 antagonist; Molecular docking; Tumor suppressor p53 |
| Core Tip |
The knowledge, at the molecular level, of the complexes formed by therapeutic drugs and their target in the body are relevant to understand the efficiency of the drug. These data can be provided, with high reliability, by bioinformatics tools, which saves time in relation to in vitro and in vivo analyses. The drug DS-3032B has been a potential candidate for oncogenic treatment in preclinical trials, but clinical studies are scarce. This work shows data on chemical interactions between this drug and its target, mouse double minute 2, that corroborate the preclinical data and demonstrate the stability of the therapeutic complex. |
| Publish Date |
2022-06-22 08:29 |
| Citation |
da Mota VHS, Freire de Melo F, de Brito BB, Silva FAFD, Teixeira KN. Molecular docking of DS-3032B, a mouse double minute 2 enzyme antagonist with potential for oncology treatment development. World J Clin Oncol 2022; 13(6): 496-504 |
| URL |
https://www.wjgnet.com/2218-4333/full/v13/i6/496.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v13.i6.496 |
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