Publication Name	World Journal of Gastroenterology
Manuscript ID	7074
Country	Japan

Received	2013-11-03 19:59
Peer-Review Started	2013-11-04 20:04
First Decision by Editorial Office Director
Return for Revision	2013-11-22 10:58
Revised	2013-12-14 00:31
Publication Fee Transferred
Second Decision by Editor	2014-01-15 20:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-01-15 20:34
Articles in Press
Edit the Manuscript by Language Editor	2014-02-10 20:59
Typeset the Manuscript	2014-05-14 20:26
Publish the Manuscript Online	2014-05-28 11:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Role of hepatitis B virus DNA integration in human hepatocarcinogenesis
Manuscript Source	Invited Manuscript
All Author List	Hoang Hai, Akihiro Tamori and Norifumi Kawada
Funding Agency and Grant Number
Corresponding Author	Akihiro Tamori, MD, PhD, Associate Professor, Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka 5458585, Japan. atamori@med.osaka-cu.ac.jp
Key Words	Hepatitis B virus; Integration; Hepatocarcinogenesis; Cis effect; Trans effect; Whole genome sequencing
Core Tip	A high viral load is associated with an elevated risk of hepatocellular carcinoma (HCC), and the risk remains increased in hepatitis B surface antigen-negative hepatitis B virus (HBV) and occult infections. The ability of HBV to integrate into the infected host’s hepatocyte genome is one of the most important direct pro-oncogenic properties. The recent development of efficient tools for genome-wide analysis of gene expression and genetic defects has allowed a comprehensive overview of the changes occurring with HCC. Specific HBV features, including the integration of viral DNA into host chromosomes, may trigger increased genetic instability.
Publish Date	2014-05-28 11:45
Citation	Hai H, Tamori A, Kawada N. Role of hepatitis B virus DNA integration in human hepatocarcinogenesis. World J Gastroenterol 2014; 20(20): 6236-6243
URL	http://www.wjgnet.com/1007-9327/full/v20/i20/6236.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i20.6236

Full Article (PDF)	WJG-20-6236.pdf
Full Article (Word)	WJG-20-6236.doc
Manuscript File	7074-Review.doc
Answering Reviewers	7074-Answering reviewers.pdf
Copyright License Agreement	7074-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7074-Language certificate.pdf
Peer-review Report	7074-Peer review(s).pdf
Scientific Editor Work List	7074-Scientific editor work list.doc