| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-inflammatory effects of quercetin via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Hsi-Lung Hsieh, Ming-Chin Yu, Li-Ching Cheng, Mei-Yi Chu, Tzu-Hao Huang, Ta-Sen Yeh and Ming-Ming Tsai |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Science and Technology, Taiwan |
MOST 108-2320-B-255-002-MY3 |
| Ministry of Science and Technology, Taiwan |
MOST 110-2635-B-255-001 |
| Chang Gung Medical Research Foundation, Taoyuan, Taiwan |
CMRPF1I0031 |
| Chang Gung Medical Research Foundation, Taoyuan, Taiwan |
CMRPF1L0081 |
| Chang Gung Medical Research Foundation, Taoyuan, Taiwan |
CMRPF1L0021 |
| Chang Gung Medical Research Foundation, Taoyuan, Taiwan |
CMRPF1L0041 |
| Chang Gung Medical Research Foundation, Taoyuan, Taiwan |
CMRPF1I0042 |
| Chang Gung University of Science and Technology, Taoyuan, Taiwan |
ZRRPF3K0111 |
| Chang Gung University of Science and Technology, Taoyuan, Taiwan |
ZRRPF3L0091 |
|
| Corresponding Author |
Ming-Ming Tsai, PhD, Associate Professor, Department of Nursing, Division of Basic Medical Sciences, Chang-Gung University of Science and Technology, No. 261 Wenhua 1st Road, Guishan District, Taoyuan 333, Taiwan. mmtsai@mail.cgust.edu.tw |
| Key Words |
Anti-inflammatory; Quercetin; Matrix metallopeptidase-9; Tumor necrosis factor-α; Normal human gastric epithelial cells |
| Core Tip |
Gastric inflammation is a common digestive system disease. Proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), and degradation induced by matrix metallopeptidases (MMPs) play a crucial role in gastric injury. We investigated whether quercetin prevents TNF-α-induced gastric inflammation in normal human gastric mucosa epithelial cell line gastric epithelial cells. Quercetin significantly blocked MMP-9 activity and cell migration and protected against TNF-α-induced gastric injury. Quercetin appeared to block TNF-α-induced gastric injury by downregulating MMP-9 via the TNF-α antagonist-c-Src–extracellular-signal-regulated kinase 1/2 and c-Jun or nuclear factor kappa B pathways. Our data suggest that quercetin, which exhibits high bioavailability, may be effective as an adjuvant therapy for the treatment of gastric inflammation. |
| Publish Date |
2022-03-17 03:25 |
| Citation |
Hsieh HL, Yu MC, Cheng LC, Chu MY, Huang TH, Yeh TS, Tsai MM. Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells. World J Gastroenterol 2022; 28(11): 1139-1158 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i11/1139.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i11.1139 |
