| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong-Jie Teng, Zhe Deng, Zhao-Guang Ouyang, Qing Zhou, Si Mei, Xing-Xing Fan, Yong-Rong Wu, Hong-Ping Long, Le-Yao Fang, Dong-Liang Yin, Bo-Yu Zhang, Yin-Mei Guo, Wen-Hao Zhu, Zhen Huang, Piao Zheng, Di-Min Ning and Xue-Fei Tian |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
U20A20408 |
| National Natural Science Foundation of China |
82074450 |
| Natural Science Foundation of Hunan Province |
2020JJ4066 |
| Hunan Province "Domestic First-class Cultivation Discipline" Integrated Traditional Chinese and Western Medicine Open Fund Project |
2020ZXYJH35 |
| Hunan Province "Domestic First-class Cultivation Discipline" Integrated Traditional Chinese and Western Medicine Open Fund Project |
2020ZXYJH34 |
| Hunan Graduate Scientific Research Innovation Project |
QL20210173 |
| Hunan Graduate Scientific Research Innovation Project |
CX20210730 |
| Hunan Province Science and Technology Innovation Talents Plan College Students Science and Technology Innovation and Entrepreneurship Project |
2020RC1004 |
| Guangzhou Health Science and Technology Project |
20221A011102 |
| Hunan Traditional Chinese Medicine Scientific Research Project |
202101 |
|
| Corresponding Author |
Xue-Fei Tian, PhD, Professor, College of Integrated Chinese and Western Medicine, Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Yuelu District, Changsha 410208, Hunan Province, China. 003640@hnucm.edu.cn |
| Key Words |
Hepatocellular carcinoma; Xihuang pills; Apoptosis; Antitumour; Phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway |
| Core Tip |
The study revealed that Xihuang pills (XHP) increases caspase-9 and caspase-3 activities by inhibiting the phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin signalling pathway and induces apoptosis and cell cycle arrest. Consequently, our study indicated that XHP inhibits the growth, migration, and proliferation of hepatocellular carcinoma (HCC) cells. Our study provides a better understanding of the antitumour effects of XHP and reveals the underlying mechanism. The findings of this study suggest that XHP might serve as a supplementary medicine in HCC treatment. |
| Publish Date |
2022-04-15 09:40 |
| Citation |
Teng YJ, Deng Z, Ouyang ZG, Zhou Q, Mei S, Fan XX, Wu YR, Long HP, Fang LY, Yin DL, Zhang BY, Guo YM, Zhu WH, Huang Z, Zheng P, Ning DM, Tian XF. Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway. World J Gastrointest Oncol 2022; 14(4): 872-886 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i4/872.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i4.872 |
