Publication Name	World Journal of Gastroenterology
Manuscript ID	71742
Country	China

Received	2021-09-20 06:20
Peer-Review Started	2021-09-20 06:23
To Make the First Decision
Return for Revision	2022-01-09 08:51
Revised	2022-01-17 08:06
Second Decision	2022-02-24 06:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-02-27 23:21
Articles in Press	2022-02-27 23:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-02-22 10:44
Typeset the Manuscript	2022-03-28 00:49
Publish the Manuscript Online	2022-03-30 15:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Li Zhang, Qian Chen, Lie Zheng, Zi-Wei Zhang, Yu-Jun Chen, Yan-Cheng Dai and Zhi-Peng Tang
ORCID	Author(s) ORCID Number Ya-Li Zhang http://orcid.org/0000-0002-8987-3558 Qian Chen http://orcid.org/0000-0002-1598-2735 Lie Zheng http://orcid.org/0000-0002-0918-0728 Zi-Wei Zhang http://orcid.org/0000-0001-6557-4062 Yu-Jun Chen http://orcid.org/0000-0001-9731-1400 Yan-Cheng Dai http://orcid.org/0000-0002-3571-077X Zhi-Peng Tang http://orcid.org/0000-0001-5695-8072
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81704009 National Natural Science Foundation of China 81873253 the Key Clinical Specialty Construction Project supported by Hongkou District Health Committee HKZK2020A01 the Sixth Round of Academic Experience Successors Training Project for Veteran Practitioner of Traditional Chinese Medicine (The document of the State Administration of Traditional Chinese Medicine 2017) 29
Corresponding Author	Zhi-Peng Tang, MD, PhD, Chief Doctor, Professor, Institute of Digestive Diseases, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. zhipengtang@sohu.com
Key Words	Inflammatory bowel disease; Osteoporosis; Jianpi Qingchang Bushen decoction; Inflammation; Bone metabolism
Core Tip	Bone loss and osteoporosis are commonly described as extra-intestinal manifestations of inflammatory bowel disease (IBD). Jianpi Qingchang Bushen decoction (JQBD) is a prescription used in clinical practice. This study aimed to evaluate the therapeutic effect of JQBD in IBD-induced bone loss and explore the underlying mechanisms. An IBD-induced bone loss model was constructed by feeding interleukin-10-knockout mice with piroxicam. The JQBD reduced inflammation of the colonic mucosa and inhibited activation of the receptor activator of nuclear factor kappa B (NF-κB)/receptor activator of NF-κB ligand/osteoprotegerin signaling pathway, thereby reducing osteoclast activation and bone resorption, improving bone metabolism.
Publish Date	2022-03-30 15:20
Citation	Zhang YL, Chen Q, Zheng L, Zhang ZW, Chen YJ, Dai YC, Tang ZP. Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss. World J Gastroenterol 2022; 28(13): 1315-1328
URL	https://www.wjgnet.com/1007-9327/full/v28/i13/1315.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i13.1315

Full Article (PDF)	WJG-28-1315.pdf
Full Article (Word)	WJG-28-1315.docx
Manuscript File	71742_Auto_Edited-JRF-Wang TQ.docx
Answering Reviewers	71742-Answering reviewers.pdf
Audio Core Tip	71742-Audio core tip.mp3
Biostatistics Review Certificate	71742-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	71742-Conflict-of-interest statement.pdf
Copyright License Agreement	71742-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	71742-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	71742-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	71742-Language certificate.pdf
Supplementary Material	71742-Supplementary material.pdf
Peer-review Report	71742-Peer-review(s).pdf
Scientific Misconduct Check	71742-Bing-Fan JR-2.png
Scientific Editor Work List	71742-Scientific editor work list.pdf
CrossCheck Report	71742-CrossCheck report.pdf
CrossCheck Report	71742-CrossCheck.png