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Articles Published Processes
3/30/2022 3:20:26 PM | Browse: 759 | Download: 2508
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Received |
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2021-09-20 06:20 |
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Peer-Review Started |
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2021-09-20 06:23 |
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First Decision by Editorial Office Director |
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2022-01-09 08:51 |
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Return for Revision |
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2022-01-09 08:51 |
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Revised |
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2022-01-17 08:06 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-02-24 06:13 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-02-27 23:21 |
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Articles in Press |
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2022-02-27 23:21 |
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Edit the Manuscript by Language Editor |
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2022-02-22 10:44 |
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Typeset the Manuscript |
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2022-03-28 00:49 |
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Publish the Manuscript Online |
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2022-03-30 15:20 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Li Zhang, Qian Chen, Lie Zheng, Zi-Wei Zhang, Yu-Jun Chen, Yan-Cheng Dai and Zhi-Peng Tang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81704009 |
| National Natural Science Foundation of China |
81873253 |
| the Key Clinical Specialty Construction Project supported by Hongkou District Health Committee |
HKZK2020A01 |
| the Sixth Round of Academic Experience Successors Training Project for Veteran Practitioner of Traditional Chinese Medicine (The document of the State Administration of Traditional Chinese Medicine 2017) |
29 |
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| Corresponding Author |
Zhi-Peng Tang, MD, PhD, Chief Doctor, Professor, Institute of Digestive Diseases, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. zhipengtang@sohu.com |
| Key Words |
Inflammatory bowel disease; Osteoporosis; Jianpi Qingchang Bushen decoction; Inflammation; Bone metabolism |
| Core Tip |
Bone loss and osteoporosis are commonly described as extra-intestinal manifestations of inflammatory bowel disease (IBD). Jianpi Qingchang Bushen decoction (JQBD) is a prescription used in clinical practice. This study aimed to evaluate the therapeutic effect of JQBD in IBD-induced bone loss and explore the underlying mechanisms. An IBD-induced bone loss model was constructed by feeding interleukin-10-knockout mice with piroxicam. The JQBD reduced inflammation of the colonic mucosa and inhibited activation of the receptor activator of nuclear factor kappa B (NF-κB)/receptor activator of NF-κB ligand/osteoprotegerin signaling pathway, thereby reducing osteoclast activation and bone resorption, improving bone metabolism. |
| Publish Date |
2022-03-30 15:20 |
| Citation |
Zhang YL, Chen Q, Zheng L, Zhang ZW, Chen YJ, Dai YC, Tang ZP. Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss. World J Gastroenterol 2022; 28(13): 1315-1328 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i13/1315.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i13.1315 |
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