| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Fertaric acid amends bisphenol A-induced toxicity, DNA breakdown, and histopathological changes in the liver, kidney, and testis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Khaled Mohamed Mohamed Koriem |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Khaled Mohamed Mohamed Koriem, PhD, Professor, Medical Physiology, National Research Centre, 33 El-Buhouth street, Dokki, Giza, Egypt, Giza 12622, Giza, Egypt. kkoriem@yahoo.com |
| Key Words |
Bisphenol A; Fertaric acid; Liver; Kidney; Testis; Toxicity; DNA |
| Core Tip |
Bisphenol A (BPA) induced a significant decrease in serum alkaline phosphatase, acid phosphatase, sodium, potassium and chloride, testosterone, dehydroepiandrosterone sulfate, glucose-6-phosphate dehydrogenase, 3β-hydroxysteroid dehydrogenase, and testis protein levels but a highly significant increase in serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transpeptidase, lactate dehydrogenase, bilirubin, urea, creatinine, uric acid, luteinizing hormone, follicle stimulating hormone, sex hormone binding globulin, blood urea nitrogen, and testis cholesterol levels. Also, fertaric acid (FA) inhibited DNA degradation in the liver, kidney, and testis. Oral administration of FA to BPA-treated rats restored all the above parameters to normal levels. Therefore, FA ameliorates BPA-induced liver, kidney, and testis toxicity, DNA breakdown, and histopathological changes. |
| Publish Date |
2022-03-24 14:13 |
| Citation |
Koriem KMM. Fertaric acid amends bisphenol A-induced toxicity, DNA breakdown, and histopathological changes in the liver, kidney, and testis. World J Hepatol 2022; 14(3): 535-550 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i3/535.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i3.535 |
