Publication Name	World Journal of Gastroenterology
Manuscript ID	72109
Country	United States

Received	2021-10-04 20:19
Peer-Review Started	2021-10-04 20:22
To Make the First Decision
Return for Revision	2021-12-04 06:35
Revised	2021-12-12 19:08
Second Decision	2022-03-22 06:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-03-27 05:34
Articles in Press	2022-03-27 05:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-04-01 14:17
Publish the Manuscript Online	2022-04-29 06:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Gut homeostasis, injury, and healing: New therapeutic targets
Manuscript Source	Invited Manuscript
All Author List	Sema Oncel and Marc D Basson
ORCID	Author(s) ORCID Number Sema Oncel http://orcid.org/0000-0001-5551-2271 Marc D Basson http://orcid.org/0000-0001-9696-2789
Funding Agency and Grant Number
Corresponding Author	Marc D Basson, MD, PhD, Professor, Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, 1301 North Columbia Road, Grand Forks, ND 58202, United States. marc.basson@und.edu
Key Words	Intestine; Mucosa; Repair; Restitution; Sheet migration; Stomach ulcer
Core Tip	The integrity of the gastrointestinal mucosa is crucial in gut homeostasis, which depends upon the balance between mucosal injury by destructive factors and healing via protective factors. An excess of destructive agents breaks down the mucosal barrier. Upon injury, under physiological conditions, gastrointestinal mucosa heals itself by complex processes. However, the gut may not heal under pathological conditions. Currently available drugs attempt to minimize or reduce injury to the gastrointestinal tract. Recent studies have focused on improving mucosal defense or directly promoting mucosal repair. This article summarizes the pathobiology of gastrointestinal mucosal healing and reviews potential new therapeutic targets.
Publish Date	2022-04-29 06:42
Citation	Oncel S, Basson MD. Gut homeostasis, injury, and healing: New therapeutic targets. World J Gastroenterol 2022; 28(17): 1725-1750
URL	https://www.wjgnet.com/1007-9327/full/v28/i17/1725.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i17.1725

Full Article (PDF)	WJG-28-1725.pdf
Full Article (Word)	WJG-28-1725.docx
Manuscript File	72109_Auto_Edited.docx
Answering Reviewers	72109-Answering reviewers.pdf
Audio Core Tip	72109-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	72109-Conflict-of-interest statement.pdf
Copyright License Agreement	72109-Copyright license agreement.pdf
Peer-review Report	72109-Peer-review(s).pdf
Scientific Misconduct Check	72109-CrossCheck.png
Scientific Misconduct Check	72109-Bing-Gong ZM-2.png
Scientific Editor Work List	72109-Scientific editor work list.pdf
CrossCheck Report	72109-CrossCheck report.pdf