Publication Name	World Journal of Orthopedics
Manuscript ID	72305
Country	India

Received	2021-10-11 11:17
Peer-Review Started	2021-10-11 11:18
First Decision by Editorial Office Director	2021-12-10 12:10
Return for Revision	2021-12-10 12:10
Revised	2021-12-11 12:17
Publication Fee Transferred
Second Decision by Editor	2022-01-25 03:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-01-26 22:23
Articles in Press	2022-01-26 22:23
Edit the Manuscript by Language Editor	2022-01-20 20:34
Typeset the Manuscript	2022-03-08 22:03
Publish the Manuscript Online	2022-03-17 11:19

ISSN	2218-5836 (online)
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Category	Infectious Diseases
Manuscript Type	Retrospective Study
Article Title	Diagnostic role of Xpert-MTB RIF assay in osteoarticular tuberculosis: A retrospective study
Manuscript Source	Invited Manuscript
All Author List	Monalisa Mohanty, Baijayantimala Mishra, Mantu Jain and Lubaib Karaniveed Puthiyapura
ORCID	Author(s) ORCID Number Monalisa Mohanty http://orcid.org/0000-0003-3940-1998 Baijayantimala Mishra http://orcid.org/0000-0002-2604-6678 Mantu Jain http://orcid.org/0000-0003-3848-4277 Lubaib Karaniveed Puthiyapura http://orcid.org/0000-0003-0837-3277
Funding Agency and Grant Number
Corresponding Author	Mantu Jain, MD, Doctor, Doctor, Surgeon, Department of Orthopaedics, AIIMS Bhubaneswar, Patrapada, Bhubaneswar 751019, Odisha, India. montu_jn@yahoo.com
Key Words	Tuberculosis; Extrapulmonary; Osteoarticular; Gene Xpert assay; Composite reference standard
Core Tip	Osteoarticular tuberculosis (OATB) is a severe form of extrapulmonary TB that needs prompt management. However, there is difficulty in collecting samples and, secondarily, the paucibacillary nature of the lesion gives poor sensitivity and reproducibility, often with long turnaround time of the routine conventional laboratory tests. Xpert MTB RIF assay has been approved by the World Health Organization for rapid diagnosis of pulmonary/extrapulmonary TB. This study aims to find the diagnostic efficiency of gene Xpert for OATB in suspected patients. We found sensitivity of gene Xpert assay, culture, and smear when compared with CRS to be 94.6%, 13.5%, and 16.2%, respectively, while specificity in all the three types of tests was 100%. The kappa percentage of agreement for gene Xpert, culture, and microscopy were found to be 95%, 20%, and 22.6%, respectively. Follow-up of the gene Xpert positive patients after getting anti-tubercular treatment revealed improvement of their conditions. We conclude that gene Xpert has higher sensitivity than other conventional tests for the timely diagnosis of OATB.
Publish Date	2022-03-17 11:19
Citation	Mohanty M, Mishra B, Jain M, Karaniveed Puthiyapura L. Diagnostic role of Xpert-MTB RIF assay in osteoarticular tuberculosis: A retrospective study. World J Orthop 2022; 13(3): 289-296
URL	https://www.wjgnet.com/2218-5836/full/v13/i3/289.htm
DOI	https://dx.doi.org/10.5312/wjo.v13.i3.289

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