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Articles Published Processes
3/17/2022 11:19:14 AM | Browse: 269 | Download: 320
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Received |
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2021-10-11 11:17 |
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Peer-Review Started |
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2021-10-11 11:18 |
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To Make the First Decision |
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Return for Revision |
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2021-12-10 12:10 |
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Revised |
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2021-12-11 12:17 |
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Second Decision |
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2022-01-25 03:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-01-26 22:23 |
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Articles in Press |
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2022-01-26 22:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-01-20 20:34 |
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Typeset the Manuscript |
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2022-03-08 22:03 |
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Publish the Manuscript Online |
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2022-03-17 11:19 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Retrospective Study |
| Article Title |
Diagnostic role of Xpert-MTB RIF assay in osteoarticular tuberculosis: A retrospective study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Monalisa Mohanty, Baijayantimala Mishra, Mantu Jain and Lubaib Karaniveed Puthiyapura |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mantu Jain, MD, Doctor, Surgeon, Department of Orthopaedics, AIIMS Bhubaneswar, Patrapada, Bhubaneswar 751019, Odisha, India. montu_jn@yahoo.com |
| Key Words |
Tuberculosis; Extrapulmonary; Osteoarticular; Gene Xpert assay; Composite reference standard |
| Core Tip |
Osteoarticular tuberculosis (OATB) is a severe form of extrapulmonary TB that needs prompt management. However, there is difficulty in collecting samples and, secondarily, the paucibacillary nature of the lesion gives poor sensitivity and reproducibility, often with long turnaround time of the routine conventional laboratory tests. Xpert MTB RIF assay has been approved by the World Health Organization for rapid diagnosis of pulmonary/extrapulmonary TB. This study aims to find the diagnostic efficiency of gene Xpert for OATB in suspected patients. We found sensitivity of gene Xpert assay, culture, and smear when compared with CRS to be 94.6%, 13.5%, and 16.2%, respectively, while specificity in all the three types of tests was 100%. The kappa percentage of agreement for gene Xpert, culture, and microscopy were found to be 95%, 20%, and 22.6%, respectively. Follow-up of the gene Xpert positive patients after getting anti-tubercular treatment revealed improvement of their conditions. We conclude that gene Xpert has higher sensitivity than other conventional tests for the timely diagnosis of OATB. |
| Publish Date |
2022-03-17 11:19 |
| Citation |
Mohanty M, Mishra B, Jain M, Karaniveed Puthiyapura L. Diagnostic role of Xpert-MTB RIF assay in osteoarticular tuberculosis: A retrospective study. World J Orthop 2022; 13(3): 289-296 |
| URL |
https://www.wjgnet.com/2218-5836/full/v13/i3/289.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v13.i3.289 |
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