Publication Name	World Journal of Clinical Cases
Manuscript ID	72361
Country	China

Received	2021-10-19 06:03
Peer-Review Started	2021-10-19 06:05
To Make the First Decision
Return for Revision	2021-12-10 02:33
Revised	2021-12-24 02:04
Second Decision	2022-01-28 03:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-01-29 07:01
Articles in Press	2022-01-29 07:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-04 22:41
Publish the Manuscript Online	2022-03-22 14:35

ISSN	2307-8960 (online)
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Category	Anesthesiology
Manuscript Type	Clinical Trials Study
Article Title	Determination of the ED95 of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography
Manuscript Source	Unsolicited Manuscript
All Author List	Yi Zou, Na Li, Liu-Jia-Zi Shao, Fu-Kun Liu, Fu-Shan Xue and Xing Tao
ORCID	Author(s) ORCID Number Yi Zou http://orcid.org/0000-0001-7520-3775 Na Li http://orcid.org/0000-0001-9195-4552 Liu-Jia-Zi Shao http://orcid.org/0000-0002-8888-1804 Fu-Kun Liu http://orcid.org/0000-0002-5997-1915 Fu-Shan Xue http://orcid.org/0000-0002-1028-6036 Xing Tao http://orcid.org/0000-0003-2420-529X
Funding Agency and Grant Number	Funding Agency Grant Number the Research Foundation of Beijing Friendship Hospital, Capital Medical University yyqdkt2018-16 the Beijing Municipal Administration of Hospitals’ Youth Program QML20190101 the Scientific Research Common Program of Beijing Municipal Commission of Education KM202010025021
Corresponding Author	Xing Tao, MD, Doctor, Doctor, Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, NO. 95 Yong-An Road, Xi-Cheng District, Beijing 100050, China. taoxing43@sina.com
Key Words	Moderate sedation; Intranasal administration; Dexmedetomidine; Sufentanil; Continual reassessment method; Endoscopic ultrasonography
Core Tip	The conventional method to preform moderate-to-deep sedation is generally intravenous benzodiazepine alone or in combination with opioids. There are many limitations to this method, including an inability for patients to tolerate it due to the possible longevity of endoscopic ultrasonography (EUS) procedures. This study aimed to provide an effective method for moderate-to-deep sedation in EUS via an intranasal approach. We believe that our study makes a significant contribution to the literature because it provides an alternative to intravenous administration by administering intranasal 1 μg/kg DEX in combination with 0.3 μg/kg sufentanil to patients scheduled for EUS.
Publish Date	2022-03-22 14:35
Citation	Zou Y, Li N, Shao LJZ, Liu FK, Xue FS, Tao X. Determination of the ED95 of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography. World J Clin Cases 2022; 10(9): 2773-2782
URL	https://www.wjgnet.com/2307-8960/full/v10/i9/2773.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i9.2773

Full Article (PDF)	WJCC-10-2773.pdf
Full Article (Word)	WJCC-10-2773.docx
Manuscript File	72361_Auto_Edited.docx
Answering Reviewers	72361-Answering reviewers.pdf
Audio Core Tip	72361-Audio core tip.mp3
Biostatistics Review Certificate	72361-Biostatistics statement.pdf
Clinical Trial Registration Statement	72361-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	72361-Conflict-of-interest statement.pdf
Copyright License Agreement	72361-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	72361-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	72361-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	72361-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	72361-Language certificate.pdf
Peer-review Report	72361-Peer-review(s).pdf
Scientific Misconduct Check	72361-Bing-Ma YJ-2.png
Scientific Editor Work List	72361-Scientific editor work list.pdf
CrossCheck Report	72361-CrossCheck Report.pdf