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4/29/2022 6:42:52 AM | Browse: 306 | Download: 643
Publication Name World Journal of Gastroenterology
Manuscript ID 72414
Country/Territory China
Received
2021-10-18 08:59
Peer-Review Started
2021-10-18 09:01
To Make the First Decision
Return for Revision
2021-12-12 06:30
Revised
2021-12-31 12:40
Second Decision
2022-03-25 06:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-03-27 05:34
Articles in Press
2022-03-27 05:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-04-24 00:16
Publish the Manuscript Online
2022-04-29 06:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Research & Experimental Medicine
Manuscript Type Basic Study
Article Title Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway
Manuscript Source Invited Manuscript
All Author List Jin-Jin Zhang, Chang-Xiong Cao, Li-Lan Wan, Wen Zhang, Zhong-Jiang Liu, Jin-Li Wang, Qiang Guo and Hui Tang
ORCID
Author(s) ORCID Number
Jin-Jin Zhang http://orcid.org/0000-0001-9261-6571
Chang-Xiong Cao http://orcid.org/0000-0002-2806-5370
Li-Lan Wan http://orcid.org/0000-0002-3489-436X
Wen Zhang http://orcid.org/0000-0002-0825-1440
Zhong-Jiang Liu http://orcid.org/0000-0003-4945-6642
Jin-Li Wang http://orcid.org/0000-0002-2371-0799
Qiang Guo http://orcid.org/0000-0003-0636-5548
Hui Tang http://orcid.org/0000-0002-8146-7184
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81502556
Yunnan Digestive Endoscopy Clinical Medical Center Foundation for Health Commission of Yunnan Province 2X2019-01-02
Corresponding Author Hui Tang, PhD, Professor, Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, the First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming 650032, Yunnan Province, China. htang1122@aliyun.com
Key Words Colorectal cancer; Forkhead Box Q1; Heparin binding epidermal growth factor; Epidermal growth factor receptor pathway; Migration; Invasion
Core Tip Invasion and metastasis play important roles in tumorigenesis, resulting in the death of most colorectal cancer (CRC) patients. Forkhead Box q1 (FOXQ1) is a well-established oncogene in multiple tumors, including CRC. Our previous study suggested that FOXQ1 positively regulates the expression of heparin-binding epidermal growth factor (HB-EGF) and triggers the activation of the epidermal growth factor receptor (EGFR) pathway in CRC. However, the role and mechanism of how FOXQ1 promotes tumorigenesis in CRC by activating the HB-EGF/EGFR pathway remain unexplored. In the present study, our findings demonstrated that the essential role of FOXQ1-induced invasion and metastasis in CRC was related to activation of the HB-EGF/EGFR pathway.
Publish Date 2022-04-29 06:42
Citation Zhang JJ, Cao CX, Wan LL, Zhang W, Liu ZJ, Wang JL, Guo Q, Tang H. Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway. World J Gastroenterol 2022; 28(17): 1781-1797
URL https://www.wjgnet.com/1007-9327/full/v28/i17/1781.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i17.1781
Full Article (PDF) WJG-28-1781.pdf
Full Article (Word) WJG-28-1781.docx
The ARRIVE Guidelines 72414-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 72414_Auto_Edited.docx
Answering Reviewers 72414-Answering reviewers.pdf
Audio Core Tip 72414-Audio core tip.m4a
Biostatistics Review Certificate 72414-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 72414-Conflict-of-interest statement.pdf
Copyright License Agreement 72414-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 72414-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 72414-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 72414-Language certificate.pdf
Peer-review Report 72414-Peer-review(s).pdf
Scientific Misconduct Check 72414-Bing-Fan JR-2.png
Scientific Editor Work List 72414-Scientific editor work list.pdf