Publication Name	World Journal of Hepatology
Manuscript ID	72483
Country	Egypt

Received	2021-10-22 19:25
Peer-Review Started	2021-10-22 19:27
To Make the First Decision
Return for Revision	2021-12-28 17:15
Revised	2022-01-14 19:47
Second Decision	2022-07-25 07:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-07-31 19:37
Articles in Press	2022-07-31 19:37
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-07-21 09:52
Typeset the Manuscript	2022-08-03 01:13
Publish the Manuscript Online	2022-08-26 09:51

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Tropical Medicine
Manuscript Type	Basic Study
Article Title	Assessment of circulating levels of microRNA-326, microRNA-424, and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians
Manuscript Source	Invited Manuscript
All Author List	Samar Samir Youssef, Asmaa Elfiky, Mohamed M Nabeel, Hend Ibrahim Shousha, Tamer Elbaz, Dalia Omran, mohammad Saeed Marie, Mohammad A Elzahry, Amr Abul-Fotouh, Ahmed Hashem, Mohamed F Guda and Ashraf O Abdelaziz
ORCID	Author(s) ORCID Number Samar Samir Youssef http://orcid.org/0000-0001-7114-4325 Asmaa Elfiky http://orcid.org/0000-0001-7730-1678 Mohamed M Nabeel http://orcid.org/0000-0001-6002-9858 Hend Ibrahim Shousha http://orcid.org/0000-0002-0928-4738 Tamer Elbaz http://orcid.org/0000-0003-0816-9575 Dalia Omran http://orcid.org/0000-0002-5513-6955 mohammad Saeed Marie http://orcid.org/0000000258930513 Mohammad A Elzahry http://orcid.org/000000193244917 Amr Abul-Fotouh http://orcid.org/000000230314372 Ahmed Hashem http://orcid.org/000000000000000000 Mohamed F Guda http://orcid.org/0000000232324320 Ashraf O Abdelaziz http://orcid.org/0000-0001-9168-7431
Funding Agency and Grant Number
Corresponding Author	Samar Samir Youssef, PhD, Professor, Microbial Biotechnology Department, National Research Centre, El Behoos st, Cairo 1211, Egypt. samaryoussef67@gmail.com
Key Words	Hepatocellular carcinoma; miRNAs-326; miRNA-424; miRNA-511; Modified response evaluation criteria in solid tumors
Core Tip	Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide. Recent cancer incidence data confirmed that the global age normalization rate of primary liver cancer is 10.1/100000, with a male/female ratio of 3:1. The diagnosis of HCC usually occurs in the late stages, resulting in an elevated death rate; this makes HCC the third deadliest malignancy. We examined whether circulating miRNAs326, miRNA-424, and miRNA-511 could serve as promising candidate non-invasive biomarkers for HCC. Such biomarkers could be used for targeted gene therapy research and may assist in monitoring the severity of HCC.
Publish Date	2022-08-26 09:51
Citation	Youssef SS, ElFiky A, Nabeel MM, Shousha HI, Elbaz T, Omran D, Marie MS, Elzahry MA, Abul-Fotouh A, Hashem A, Guda MF, Abdelaziz AO. Assessment of circulating levels of microRNA-326, microRNA-424, and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians. World J Hepatol 2022; 14(8): 1562-1575
URL	https://www.wjgnet.com/1948-5182/full/v14/i8/1562.htm
DOI	https://dx.doi.org/10.4254/wjh.v14.i8.1562

Full Article (PDF)	WJH-14-1562.pdf
Full Article (Word)	WJH-14-1562.docx
Manuscript File	72483_Auto_Edited-YJM-Webster J-LS.docx
Answering Reviewers	72483-Answering reviewers.pdf
Audio Core Tip	72483-Audio core tip.mp3
Biostatistics Review Certificate	72483-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	72483-Conflict-of-interest statement.pdf
Copyright License Agreement	72483-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	72483-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	72483-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	72483-Language certificate.pdf
Peer-review Report	72483-Peer-review(s).pdf
Scientific Misconduct Check	72483-Bing-Ma YJ-2.png
Scientific Editor Work List	72483-Scientific editor work list.pdf