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Articles Published Processes
3/3/2022 6:59:41 AM | Browse: 725 | Download: 2164
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Received |
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2021-11-10 09:16 |
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Peer-Review Started |
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2021-11-10 09:16 |
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First Decision by Editorial Office Director |
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2021-12-03 20:05 |
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Return for Revision |
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2021-12-03 20:05 |
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Revised |
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2021-12-14 12:42 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-01-21 05:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-01-22 20:25 |
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Articles in Press |
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2022-01-22 20:25 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-02-21 02:14 |
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Publish the Manuscript Online |
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2022-03-03 06:59 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-κB pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Wei Dong, Hui Liu, Fei-Fei Su, Xiao-Zhou Fan, Yong Zhang and Peng Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81800473 |
| "Young Eagle Project "of Air Force Medical University |
KT2021DX007 |
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| Corresponding Author |
Peng Liu, PhD, Research Scientist, Research Laboratory of Aero-Medical Support, Air Force Medical Center, No. 30 Fucheng Road, Haidian District, Beijing 100000, China. liupeng-81@foxmail.com |
| Key Words |
Apoptosis; Cystic fibrosis transmembrane conductance regulator; Intestinal ischemia-reperfusion injury; PI3K/AKT/NF-κB; Hypoxia/reoxygenation; Caco2 cells |
| Core Tip |
Intestinal ischemia/reperfusion (I/R) injury is a fatal syndrome that occurs under many clinical scenarios. The apoptosis of intestinal cells caused by ischemia can cause cell damage and provoke systemic dysfunction during reperfusion. However, the mechanism of I/R-induced apoptosis remains unclear. In our paper, our data demonstrate that cystic fibrosis transmembrane conductance regulator (CFTR) is downregulated in hypoxia/reoxygenation (H/R)-treated Caco2 cells, and overexpression of CFTR protects Caco2 cells from H/R-induced apoptosis. Additionally, CFTR is involved in inhibiting H/R-induced apoptosis, and it inhibits apoptosis through PI3K/AKT/NF-κB signaling pathway. In all, this work suggests that overexpression of CFTR attenuates H/R-induced apoptosis through PI3K/AKT/NF-κB signaling pathway in H/R-treated Caco2 cells. |
| Publish Date |
2022-03-03 06:59 |
| Citation |
Dong ZW, Liu H, Su FF, Fan XZ, Zhang Y, Liu P. Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-κB pathway. World J Gastroenterol 2022; 28(9): 918-932
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| URL |
https://www.wjgnet.com/1007-9327/full/v28/i9/918.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i9.918 |
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