Publication Name	World Journal of Gastroenterology
Manuscript ID	72524
Country	China

Received	2021-11-10 09:16
Peer-Review Started	2021-11-10 09:16
First Decision by Editorial Office Director	2021-12-03 20:05
Return for Revision	2021-12-03 20:05
Revised	2021-12-14 12:42
Publication Fee Transferred
Second Decision by Editor	2022-01-21 05:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-01-22 20:25
Articles in Press	2022-01-22 20:25
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-02-21 02:14
Publish the Manuscript Online	2022-03-03 06:59

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-κB pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Wei Dong, Hui Liu, Fei-Fei Su, Xiao-Zhou Fan, Yong Zhang and Peng Liu
ORCID	Author(s) ORCID Number Zhi-Wei Dong http://orcid.org/0000-0001-7009-9331 Hui Liu http://orcid.org/0000-0003-4721-560X Fei-Fei Su http://orcid.org/0000-0001-9816-1491 Xiao-Zhou Fan http://orcid.org/0000-0002-8280-4146 Yong Zhang http://orcid.org/0000-0001-9650-4294 Peng Liu http://orcid.org/0000-0002-8063-6214
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81800473 "Young Eagle Project "of Air Force Medical University KT2021DX007
Corresponding Author	Peng Liu, PhD, Research Scientist, Research Laboratory of Aero-Medical Support, Air Force Medical Center, No. 30 Fucheng Road, Haidian District, Beijing 100000, China. liupeng-81@foxmail.com
Key Words	Apoptosis; Cystic fibrosis transmembrane conductance regulator; Intestinal ischemia-reperfusion injury; PI3K/AKT/NF-κB; Hypoxia/reoxygenation; Caco2 cells
Core Tip	Intestinal ischemia/reperfusion (I/R) injury is a fatal syndrome that occurs under many clinical scenarios. The apoptosis of intestinal cells caused by ischemia can cause cell damage and provoke systemic dysfunction during reperfusion. However, the mechanism of I/R-induced apoptosis remains unclear. In our paper, our data demonstrate that cystic fibrosis transmembrane conductance regulator (CFTR) is downregulated in hypoxia/reoxygenation (H/R)-treated Caco2 cells, and overexpression of CFTR protects Caco2 cells from H/R-induced apoptosis. Additionally, CFTR is involved in inhibiting H/R-induced apoptosis, and it inhibits apoptosis through PI3K/AKT/NF-κB signaling pathway. In all, this work suggests that overexpression of CFTR attenuates H/R-induced apoptosis through PI3K/AKT/NF-κB signaling pathway in H/R-treated Caco2 cells.
Publish Date	2022-03-03 06:59
Citation	Dong ZW, Liu H, Su FF, Fan XZ, Zhang Y, Liu P. Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-κB pathway. World J Gastroenterol 2022; 28(9): 918-932
URL	https://www.wjgnet.com/1007-9327/full/v28/i9/918.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i9.918

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