Publication Name	World Journal of Gastroenterology
Manuscript ID	72524
Country	China

Received	2021-11-10 09:16
Peer-Review Started	2021-11-10 09:16
To Make the First Decision
Return for Revision	2021-12-03 20:05
Revised	2021-12-14 12:42
Second Decision	2022-01-21 05:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-01-22 20:25
Articles in Press	2022-01-22 20:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-02-21 02:14
Publish the Manuscript Online	2022-03-03 06:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-κB pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Wei Dong, Hui Liu, Fei-Fei Su, Xiao-Zhou Fan, Yong Zhang and Peng Liu
ORCID	Author(s) ORCID Number Zhi-Wei Dong http://orcid.org/0000-0001-7009-9331 Hui Liu http://orcid.org/0000-0003-4721-560X Fei-Fei Su http://orcid.org/0000-0001-9816-1491 Xiao-Zhou Fan http://orcid.org/0000-0002-8280-4146 Yong Zhang http://orcid.org/0000-0001-9650-4294 Peng Liu http://orcid.org/0000-0002-8063-6214
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81800473 "Young Eagle Project "of Air Force Medical University KT2021DX007
Corresponding Author	Peng Liu, PhD, Research Scientist, Research Laboratory of Aero-Medical Support, Air Force Medical Center, No. 30 Fucheng Road, Haidian District, Beijing 100000, China. liupeng-81@foxmail.com
Key Words	Apoptosis; Cystic fibrosis transmembrane conductance regulator; Intestinal ischemia-reperfusion injury; PI3K/AKT/NF-κB; Hypoxia/reoxygenation; Caco2 cells
Core Tip	Intestinal ischemia/reperfusion (I/R) injury is a fatal syndrome that occurs under many clinical scenarios. The apoptosis of intestinal cells caused by ischemia can cause cell damage and provoke systemic dysfunction during reperfusion. However, the mechanism of I/R-induced apoptosis remains unclear. In our paper, our data demonstrate that cystic fibrosis transmembrane conductance regulator (CFTR) is downregulated in hypoxia/reoxygenation (H/R)-treated Caco2 cells, and overexpression of CFTR protects Caco2 cells from H/R-induced apoptosis. Additionally, CFTR is involved in inhibiting H/R-induced apoptosis, and it inhibits apoptosis through PI3K/AKT/NF-κB signaling pathway. In all, this work suggests that overexpression of CFTR attenuates H/R-induced apoptosis through PI3K/AKT/NF-κB signaling pathway in H/R-treated Caco2 cells.
Publish Date	2022-03-03 06:59
Citation	Dong ZW, Liu H, Su FF, Fan XZ, Zhang Y, Liu P. Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-κB pathway. World J Gastroenterol 2022; 28(9): 918-932
URL	https://www.wjgnet.com/1007-9327/full/v28/i9/918.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i9.918

Full Article (PDF)	WJG-28-918.pdf
Full Article (Word)	WJG-28-918.docx
The ARRIVE Guidelines	72524-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	72524_Auto_Edited.docx
Answering Reviewers	72524-Answering reviewers.pdf
Audio Core Tip	72524-Audio core tip.aac
Biostatistics Review Certificate	72524-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	72524-Conflict-of-interest statement.pdf
Copyright License Agreement	72524-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	72524-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	72524-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	72524-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	72524-Language certificate.pdf
Peer-review Report	72524-Peer-review(s).pdf
Scientific Misconduct Check	72524-Bing-Fan JR-2.png
Scientific Editor Work List	72524-Scientific editor work list.pdf
CrossCheck Report	72524-CrossCheck report.pdf
CrossCheck Report	72524-CrossCheck.png