Publication Name	World Journal of Clinical Cases
Manuscript ID	72702
Country	China

Received	2021-11-01 08:19
Peer-Review Started	2021-11-01 08:20
To Make the First Decision
Return for Revision	2022-03-23 00:55
Revised	2022-04-06 08:12
Second Decision	2022-05-19 03:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-05-22 23:31
Articles in Press	2022-05-22 23:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-06-26 12:21
Publish the Manuscript Online	2022-07-05 01:22

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Case Report
Article Title	Clinical features and genetic variations of severe neonatal hyperbilirubinemia: Five case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Fen Lin, Jian-Xin Xu, Yong-Hao Wu, Yu-Bin Ma and Li-Ye Yang
ORCID	Author(s) ORCID Number Fen Lin http://orcid.org/0000-0001-9614-7776 Jian-Xin Xu http://orcid.org/0000-0002-3431-6834 Yong-Hao Wu http://orcid.org/0000-0002-6795-1201 Yu-Bin Ma http://orcid.org/0000-0003-4225-4829 Li-Ye Yang http://orcid.org/0000-0001-9603-187X
Funding Agency and Grant Number
Corresponding Author	Li-Ye Yang, MD, Professor, Precision Medical Lab Center, People’s Hospital of Yangjiang Affiliated to Guangdong Medical University, No. 42 Dongshan Road, Jiangcheng District, Yangjiang 529500, Guangdong Province, China. yangleeyee@sina.com
Key Words	Neonatal hyperbilirubinemia; Gene variation; Next generation sequencing; Clinical feature; Case report
Core Tip	This study has emphasized that for severe hyperbilirubinemia neonates, apart from the predominant glucose-6-phosphate dehydrogenase deficiency and ABO hemolysis, other underlying genetic factors such as thalassemia or red blood cell membrane disorders should be considered, and genetic detection may be taken into consideration for early diagnosis of severe hyperbilirubinemia in neonates.
Publish Date	2022-07-05 01:22
Citation	Lin F, Xu JX, Wu YH, Ma YB, Yang LY. Clinical features and genetic variations of severe neonatal hyperbilirubinemia: Five case reports. World J Clin Cases 2022; 10(20): 6999-7005
URL	https://www.wjgnet.com/2307-8960/full/v10/i20/6999.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i20.6999

Full Article (PDF)	WJCC-10-6999.pdf
Full Article (Word)	WJCC-10-6999.docx
Manuscript File	72702_Auto_Edited-LS.docx
Answering Reviewers	72702-Answering reviewers.pdf
Audio Core Tip	72702-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	72702-Conflict-of-interest statement.pdf
Copyright License Agreement	72702-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	72702-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	72702-Language certificate.pdf
Peer-review Report	72702-Peer-review(s).pdf
Scientific Editor Work List	72702-Scientific editor work list.pdf
CrossCheck Report	72702-Informed consent statement.pdf