Publication Name	World Journal of Clinical Cases
Manuscript ID	72929
Country	China

Received	2021-11-03 08:51
Peer-Review Started	2021-11-03 08:52
To Make the First Decision
Return for Revision	2021-12-27 07:24
Revised	2022-01-10 08:22
Second Decision	2022-04-24 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-04-24 19:39
Articles in Press	2022-04-24 19:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-04-11 10:51
Typeset the Manuscript	2022-06-01 13:09
Publish the Manuscript Online	2022-06-17 03:19

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Development of clustered regularly interspaced short palindromic repeats/CRISPR-associated technology for potential clinical applications
Manuscript Source	Unsolicited Manuscript
All Author List	Yue-Ying Huang, Xiao-Yu Zhang, Ping Zhu and Ling Ji
ORCID	Author(s) ORCID Number Yue-Ying Huang http://orcid.org/0000-0002-9591-0490 Xiao-Yu Zhang http://orcid.org/0000-0002-8887-4946 Ping Zhu http://orcid.org/0000-0002-2787-1522 Ling Ji http://orcid.org/0000-0003-4088-2514
Funding Agency and Grant Number	Funding Agency Grant Number Shenzhen Science and Technology R&D Fund JCYJ20190809095203586
Corresponding Author	Ling Ji, Doctor, Chief Technician, Department of Laboratory Medicine, Peking University Shenzhen Hospital, No. 1120 Lianhua Road , Futian District, Shenzhen 518035, Guangdong Province, China. 1120303921@qq.com
Key Words	CRISPR-Cas; Gene editing; Molecular diagnostics; Gene targeting
Core Tip	This review mainly discusses and explores the potential clinical applications of the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) technology. The detection technologies for nucleic acids and small molecules of different pathogens based on the CRISPR/Cas system are summarized. The advantages and disadvantages of the CRISPR/Cas technology from the aspects of gene editing, disease treatment, multi-drug resistance, and treatment are enumerated, asserting that CRISPR/Cas system has unlimited potential in clinical applications with certain challenges.
Publish Date	2022-06-17 03:19
Citation	Huang YY, Zhang XY, Zhu P, Ji L. Development of clustered regularly interspaced short palindromic repeats/CRISPR-associated technology for potential clinical applications. World J Clin Cases 2022; 10(18): 5934-5945
URL	https://www.wjgnet.com/2307-8960/full/v10/i18/5934.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i18.5934

Full Article (PDF)	WJCC-10-5934.pdf
Full Article (Word)	WJCC-10-5934.docx
Manuscript File	72929_Auto_Edited-YLC-Webster JR.docx
Answering Reviewers	72929-Answering reviewers.pdf
Audio Core Tip	72929-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	72929-Conflict-of-interest statement.pdf
Copyright License Agreement	72929-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	72929-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	72929-Language certificate.pdf
Peer-review Report	72929-Peer-review(s).pdf
Scientific Misconduct Check	72929-Bing-Chen YL-2.png
Scientific Editor Work List	72929-Scientific editor work list.pdf
CrossCheck Report	72929-CrossCheck report.pdf