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5/12/2022 8:42:29 AM | Browse: 363 | Download: 814
Publication Name World Journal of Gastroenterology
Manuscript ID 72974
Country China
Received
2021-12-07 04:59
Peer-Review Started
2021-12-07 05:00
To Make the First Decision
Return for Revision
2022-01-27 07:58
Revised
2022-02-01 01:08
Second Decision
2022-03-22 06:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2022-03-27 05:25
Articles in Press
2022-03-27 05:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-03-18 03:02
Typeset the Manuscript
2022-05-04 04:18
Publish the Manuscript Online
2022-05-12 08:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Microbiology
Manuscript Type Basic Study
Article Title Gut mucosal microbiota profiles linked to colorectal cancer recurrence
Manuscript Source Invited Manuscript
All Author List Rui-Xue Huo, Yi-Jia Wang, Shao-Bin Hou, Wei Wang, Chun-Ze Zhang and Xue-Hua Wan
ORCID
Author(s) ORCID Number
Rui-Xue Huo http://orcid.org/0000-0001-5755-4934
Yi-Jia Wang http://orcid.org/0000-0002-4026-9245
Shao-Bin Hou http://orcid.org/0000-0003-3467-8242
Wei Wang http://orcid.org/0000-0002-6660-8540
Chun-Ze Zhang http://orcid.org/0000-0002-2063-5631
Xue-Hua Wan http://orcid.org/0000-0002-6367-848X
Funding Agency and Grant Number
Funding Agency Grant Number
Tianjin Science and Technology Plan Project 19YFZCSY00170
Tianjin Union Medical Center 2019YJ007
Beijing Medical and Health Foundation F1814B
Key R&D Projects in the Tianjin Science and Technology Pillar Program 19YFZCSY00420
National Key R&D Program of China 2017YFC1700606
National Key R&D Program of China 2017YFC1700604
Corresponding Author Xue-Hua Wan, PhD, Assistant Professor, Senior Researcher, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, No. 23 Hongda Street, Tianjin 300457, China. xuehua.wan@nankai.edu.cn
Key Words Gut microbiota; Colorectal cancer; Prognosis; Colorectal cancer recurrence; Biomarker; 16S rRNA sequencing analysis
Core Tip Emerging evidence indicates that besides genetic and epigenetic factors, the gut microbiota is capable of driving colorectal cancer (CRC) progression. Here, we analyzed the gut mucosal microbiota of 75 triplet-paired samples collected from on-tumor, adjacent-tumor and off-tumor sites of patients diagnosed with/without CRC recurrence and 26 healthy controls. After a long-term follow-up, we identified spatial-specific bacterial taxa whose abundances are associated with overall survival and disease-free survival. Our data reveal the profiles of gut mucosal microbiota that increase risk of CRC recurrence and affect patient prognosis, which may serve as potential new biomarkers for CRC diagnosis.
Publish Date 2022-05-12 08:42
Citation Huo RX, Wang YJ, Hou SB, Wang W, Zhang CZ, Wan XH. Gut mucosal microbiota profiles linked to colorectal cancer recurrence. World J Gastroenterol 2022; 28(18): 1946-1964
URL https://www.wjgnet.com/1007-9327/full/v28/i18/1946.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i18.1946
Full Article (PDF) WJG-28-1946.pdf
Full Article (Word) WJG-28-1946.docx
Manuscript File 72974_Auto_Edited.docx
Answering Reviewers 72974-Answering reviewers.pdf
Audio Core Tip 72974-Audio core tip.mp3
Biostatistics Review Certificate 72974-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 72974-Conflict-of-interest statement.pdf
Copyright License Agreement 72974-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 72974-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 72974-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 72974-Language certificate.pdf
Supplementary Material 72974-Supplementary material.pdf
Peer-review Report 72974-Peer-review(s).pdf
Scientific Editor Work List 72974-Scientific editor work list.pdf
CrossCheck Report 72974-CrossCheck report.pdf