BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/26/2022 7:50:06 AM | Browse: 480 | Download: 2126
 |
Received |
|
2021-11-10 07:00 |
|
Peer-Review Started |
|
2021-11-10 07:02 |
|
First Decision by Editorial Office Director |
|
2022-01-09 08:18 |
|
Return for Revision |
|
2022-01-09 08:18 |
|
Revised |
|
2022-01-17 05:26 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2022-07-13 02:49 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2022-07-17 23:42 |
|
Articles in Press |
|
2022-07-17 23:42 |
|
Edit the Manuscript by Language Editor |
|
2022-07-08 03:19 |
|
Typeset the Manuscript |
|
2022-08-17 09:01 |
|
Publish the Manuscript Online |
|
2022-08-26 07:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1α-mediated glycolysis in hepatocellular carcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Lin Zhou, Yang Zhao, Li-Chao Pan, Jing Wang, Xian-Jie Shi, Guo-Sheng Du and Qiang He |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Guo-Sheng Du, MD, Professor, Faculty of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. duguosheng309@126.com |
| Key Words |
Hepatocellular carcinoma; Sirolimus; Huai Er; Warburg effect; Hypoxia inducible factor-1α |
| Core Tip |
Hypoxia-mediated glycolysis is associated with poorly differentiated hepatocellular carcinoma (HCC) and a poor prognosis. Hypoxia inducible factor-1α (HIF-1α), induced by hypoxia, promotes the growth of HepG2 and Huh7 cells and weakens the anti-cancer effect of sirolimus (SRL) and Huai Er. SRL increased the anti-cancer effect of Huai Er, which reduced the promotion of hypoxia-induced HIF-1α on the Warburg effect by inhibiting the PI3K/Akt/mammalian target of rapamycin-HIF-1α and HIF-1α-phosphatase and tensin homolog deleted on chromosome ten signalling pathways in HCC. |
| Publish Date |
2022-08-26 07:50 |
| Citation |
Zhou L, Zhao Y, Pan LC, Wang J, Shi XJ, Du GS, He Q. Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1α-mediated glycolysis in hepatocellular carcinoma. World J Gastroenterol 2022; 28(32): 4600-4619
|
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i32/4600.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i32.4600 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
