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Articles Published Processes
8/26/2022 7:50:06 AM | Browse: 304 | Download: 1034
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Received |
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2021-11-10 07:00 |
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Peer-Review Started |
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2021-11-10 07:02 |
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To Make the First Decision |
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Return for Revision |
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2022-01-09 08:18 |
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Revised |
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2022-01-17 05:26 |
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Second Decision |
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2022-07-13 02:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-07-17 23:42 |
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Articles in Press |
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2022-07-17 23:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-07-08 03:19 |
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Typeset the Manuscript |
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2022-08-17 09:01 |
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Publish the Manuscript Online |
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2022-08-26 07:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1α-mediated glycolysis in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lin Zhou, Yang Zhao, Li-Chao Pan, Jing Wang, Xian-Jie Shi, Guo-Sheng Du and Qiang He |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guo-Sheng Du, MD, Professor, Faculty of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. duguosheng309@126.com |
| Key Words |
Hepatocellular carcinoma; Sirolimus; Huai Er; Warburg effect; Hypoxia inducible factor-1α |
| Core Tip |
Hypoxia-mediated glycolysis is associated with poorly differentiated hepatocellular carcinoma (HCC) and a poor prognosis. Hypoxia inducible factor-1α (HIF-1α), induced by hypoxia, promotes the growth of HepG2 and Huh7 cells and weakens the anti-cancer effect of sirolimus (SRL) and Huai Er. SRL increased the anti-cancer effect of Huai Er, which reduced the promotion of hypoxia-induced HIF-1α on the Warburg effect by inhibiting the PI3K/Akt/mammalian target of rapamycin-HIF-1α and HIF-1α-phosphatase and tensin homolog deleted on chromosome ten signalling pathways in HCC. |
| Publish Date |
2022-08-26 07:50 |
| Citation |
Zhou L, Zhao Y, Pan LC, Wang J, Shi XJ, Du GS, He Q. Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1α-mediated glycolysis in hepatocellular carcinoma. World J Gastroenterol 2022; 28(32): 4600-4619 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i32/4600.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i32.4600 |
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