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2/28/2022 11:14:01 AM | Browse: 389 | Download: 837
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Received |
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2021-11-21 03:39 |
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Peer-Review Started |
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2021-11-21 03:41 |
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To Make the First Decision |
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Return for Revision |
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2021-12-10 12:19 |
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Revised |
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2021-12-10 22:04 |
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Second Decision |
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2022-02-22 03:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-02-23 20:48 |
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Articles in Press |
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2022-02-23 20:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-02-25 01:01 |
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Publish the Manuscript Online |
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2022-02-28 11:14 |
| ISSN |
2308-3840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Uses of knockout, knockdown, and transgenic models in the studies of glucose transporter 4
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tian-Nan Wang, Xin-Ge Hu and Guo-Xun Chen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guo-Xun Chen, PhD, Associate Professor, Research Scientist, Department of Nutrition , The University of Tennessee, Knoxville, Room 229, Jessie Harris Building
1215 West Cumberland Avenue, Knoxville, Tennessee 37996, United States. gchen6@utk.edu |
| Key Words |
Glucose transporter 4; Knockout; Knockdown; Transgene; Overexpression; Insulin |
| Core Tip |
The whole body GLUT4-null mice have growth retardation, but normal glucose tolerance and basal glucose turnover rates. The muscle-specific GLUT4 knockout mice have normal body weight and fat pad weight at least before 6 mo of age, whereas the adipose-GLUT4 knockout mice have glucose intolerance. The adipose and muscle GLUT4 double knockout mice develop hyperglycemia in the fasting state, suggesting the role of GLUT4 in fasting state. Compared to the control mice, whole-body GLUT4 transgenic mice have similar growth rate before 10 wk of age, lower blood glucose in the fasting, and lower insulin level in the fed state. The adipose tissue specific GLUT4 overexpression increases body weight, glucose transport rate and adipose tissue weight. Data from both transgenic overexpression and tissue specific knockout of GLUT4 indicate that GLUT4 probably plays a role in the glucose uptake in the fasting state. |
| Publish Date |
2022-02-28 11:14 |
| Citation |
Wang TN, Hu XG, Chen GX. Uses of knockout, knockdown, and transgenic models in the studies of glucose transporter 4. World J Meta-Anal 2022; 10(1): 1-11 |
| URL |
https://www.wjgnet.com/2308-3840/full/v10/i1/1.htm |
| DOI |
https://dx.doi.org/10.13105/wjma.v10.i1.1 |
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