Publication Name	World Journal of Biological Chemistry
Manuscript ID	7349
Country	Brazil

Received	2013-11-14 08:20
Peer-Review Started	2013-11-15 10:39
To Make the First Decision	2014-01-15 16:31
Return for Revision	2014-01-20 16:41
Revised	2014-02-10 21:09
Second Decision	2014-03-18 15:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-18 15:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-25 23:29
Typeset the Manuscript	2014-05-19 12:09
Publish the Manuscript Online	2014-06-11 10:30

ISSN	1949-8454 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Review
Article Title	What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders?
Manuscript Source	Invited Manuscript
All Author List	Maria da Graça Naffah-Mazzacoratti, Telma Luciana Furtado Gouveia, Priscila Santos Rodrigues Simões and Sandra Regina Perosa
Funding Agency and Grant Number	Funding Agency Grant Number Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Instituto Nacional de Neurociência Translacional (INNT), Programa de Núcleos de Excelência (PRONEX) (Brazil)
Corresponding Author	Maria da Graca Naffah-Mazzacoratti, PhD, Departamento de Bioquímica, Universidade Federal de Sao Paulo, Rua Pedro de Toledo 669, segundo andar, Sao Paulo, SP 4039032, Brasil. naffahmazzacoratti@gmail.com
Key Words	Kallikrein-kinin system; Renin-angiotensin system; Neurological disorders; Alzheimer’s disease; Epilepsy; Parkinson’s disease
Core Tip	This review is a description of the involvement of the kallikrein-kinin and renin-angiotensin systems in neurological disorders. We describe all components of both systems, relating them to several brain diseases such as Alzheimer’s disease, Parkinson’s disease, epilepsy, multiple sclerosis, blood brain barrier disruption, stroke and inflammation, including the involvement of each molecule, their receptor and specific enzymes in individual pathologies. We also show that brain homeostasis depends on a dynamic balance between the kallikrein-kinin and renin-angiotensin systems.
Publish Date	2014-06-11 10:30
Citation	Naffah-Mazzacoratti MG, Gouveia TLF, Simões PSR, Perosa SR. What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders? World J Biol Chem 2014; 5(2): 130-140
URL	http://www.wjgnet.com/1949-8454/full/v5/i2/130.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i2.130

Full Article (PDF)	wjbc-5-130.pdf
Full Article (Word)	wjbc-5-130.doc
Manuscript File	7349-Review.docx
Answering Reviewers	7349-Answering reviewers.pdf
Copyright License Agreement	7349-Copyright assignment.pdf
Peer-review Report	7349-Peer reviews.pdf
Scientific Editor Work List	7349-Scientific editor work list.doc