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Articles Published Processes
5/24/2022 10:35:19 AM | Browse: 401 | Download: 957
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Received |
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2021-11-30 11:09 |
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Peer-Review Started |
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2021-11-30 11:11 |
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To Make the First Decision |
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Return for Revision |
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2021-12-27 20:33 |
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Revised |
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2022-01-31 07:08 |
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Second Decision |
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2022-04-21 02:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-04-25 20:07 |
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Articles in Press |
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2022-04-25 20:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-04-05 14:16 |
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Typeset the Manuscript |
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2022-05-07 02:08 |
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Publish the Manuscript Online |
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2022-05-24 10:35 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Role of hepatitis B virus in development of hepatocellular carcinoma: Focus on covalently closed circular DNA
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Claryssa Bianca, Elizabeth Sidhartha, Claudio Tiribelli, Korri Elvanita El-Khobar and Caecilia H C Sukowati |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Regione of Friuli Venezia Giulia, Italy |
DGR 189 dd 12/2/21 to the FIF |
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| Corresponding Author |
Caecilia H C Sukowati, BSc, PhD, Senior Researcher, Centro Studi Fegato, Fondazione Italiana Fegato ONLUS, AREA Science Park, campus Basovizza, SS14 km 163.5, Trieste 34149, Italy. caecilia.sukowati@fegato.it |
| Key Words |
Hepatitis B virus; Covalently closed circular DNA; Hepatocellular carcinoma; Hepatocarcinogenesis |
| Core Tip |
The covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) in human hepatocytes serves as the template for viral replication machinery. HBV cccDNA is also related to host immune response and persistent HBV infection leading to the development of hepatocellular carcinoma. This review summarizes current knowledge on cccDNA in hepatocarcinogenesis and comprehensive efforts to its detection and targeting. |
| Publish Date |
2022-05-24 10:35 |
| Citation |
Bianca C, Sidhartha E, Tiribelli C, El-Khobar KE, Sukowati CHC. Role of hepatitis B virus in development of hepatocellular carcinoma: Focus on covalently closed circular DNA. World J Hepatol 2022;14(5): 866-884 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i5/866.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i5.866 |
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