Publication Name	World Journal of Clinical Cases
Manuscript ID	73709
Country	China

Received	2021-12-04 08:19
Peer-Review Started	2021-12-04 08:21
To Make the First Decision
Return for Revision	2022-01-25 07:55
Revised	2022-01-27 13:27
Second Decision	2022-05-24 03:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-05-28 06:50
Articles in Press	2022-05-28 06:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-08 04:01
Typeset the Manuscript	2022-06-17 00:51
Publish the Manuscript Online	2022-07-11 08:36

ISSN	2307-8960 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Case Report
Article Title	Novel SLC12A3 compound heterozygous mutation in Gitelman syndrome co-existent with hyperthyroidism: A case report and literature review
Manuscript Source	Unsolicited Manuscript
All Author List	Yong-Zhang Qin, Yan-Ming Liu, Yang Wang, Cong You, Long-Nian Li, Xue-Yan Zhou, Wei-Min Lv, Shi-Hua Hong and Li-Xia Xiao
ORCID	Author(s) ORCID Number Yong-Zhang Qin http://orcid.org/0000-0002-8148-0864 Yan-Ming Liu http://orcid.org/0000-0002-3430-2635 Yang Wang http://orcid.org/0000-0002-6260-8033 Cong You http://orcid.org/0000-0002-0314-5884 Long-Nian Li http://orcid.org/0000-0002-3441-037X Xue-Yan Zhou http://orcid.org/0000-0001-5601-6093 Wei-Min Lv http://orcid.org/0000-0002-7399-382X Shi-Hua Hong http://orcid.org/0000-0002-5054-671X Li-Xia Xiao http://orcid.org/0000-0002-4902-9360
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Plan of Health Commission of Jiangxi Province 202130648 Science and Technology Research Project of Department of Education of Jiangxi Province GJJ201522
Corresponding Author	Li-Xia Xiao, MD, Associate Chief Physician, Department of Endocrinology, The First Affiliated Hospital of Gannan Medical University, No. 128 Jinling Road, Ganzhou 341000, Jiangxi Province, China. xlx981107@163.com
Key Words	SLC12A3; Gitelman syndrome; Hyperthyroidism; Hypokalemia; Gene sequencing; Case report
Core Tip	In the present study, we report a patient with hyperthyroidism who was diagnosed with Gitelman syndrome (GS) through genome sequencing. We identified a novel compound heterozygous mutation in SLC12A3. Protein molecular modeling was performed to predict the effects of the identified missense mutations, which cause changes in protein structure and may result in abnormal protein function. All previously reported cases of GS coexisting with autoimmune thyroid disease were reviewed.
Publish Date	2022-07-11 08:36
Citation	Qin YZ, Liu YM, Wang Y, You C, Li LN, Zhou XY, Lv WM, Hong SH, Xiao LX. Novel compound heterozygous mutation of SLC12A3 in Gitelman syndrome co-existent with hyperthyroidism: A case report and literature review. World J Clin Cases 2022; 10(21): 7483-7494
URL	https://www.wjgnet.com/2307-8960/full/v10/i21/7483.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i21.7483

Full Article (PDF)	WJCC-10-7483.pdf
Full Article (Word)	WJCC-10-7483.docx
Manuscript File	73709_Auto_Edited-LS_WangTQ.docx
Answering Reviewers	73709-Answering reviewers.pdf
Audio Core Tip	73709-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	73709-Conflict-of-interest statement.pdf
Copyright License Agreement	73709-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	73709-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	73709-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	73709-Language certificate.pdf
Peer-review Report	73709-Peer-review(s).pdf
Scientific Misconduct Check	73709-Bing-Wang JJ-2.png
Scientific Editor Work List	73709-Scientific editor work list.pdf
CrossCheck Report	73709-CrossCheck report.pdf