BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/18/2014 7:49:00 PM | Browse: 9163 | Download: 1329
 |
Received |
|
2013-11-20 12:12 |
|
Peer-Review Started |
|
2013-11-21 17:54 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2013-12-26 17:13 |
|
Revised |
|
|
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2014-04-03 10:17 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2014-04-03 11:21 |
|
Articles in Press |
|
2014-05-23 09:54 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2014-08-27 09:40 |
|
Publish the Manuscript Online |
|
2014-09-18 19:50 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Nuclear receptors and pathogenesis of pancreatic cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Simone Polvani, Mirko Tarocchi, Sara Tempesti and Andrea Galli |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fondo per gli Investimenti della Ricerca di Base (FIRB) |
RBAP10MY35_002 |
| Ente Cassa di Risparmio di Firenze |
|
| FiorGen ONLUS |
to Galli A |
|
| Corresponding Author |
Andrea Galli, Professor, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, 50134 Florence, Italy. a.galli@dfc.unifi.it |
| Key Words |
Peroxisome proliferator activated receptor; Pancreatic intraepithelial neoplasia; COUP-TFⅡ; Nuclear receptors; Orphan nuclear receptor; Nuclear receptors 4A2; Nuclear receptors 2F2; Pancreatic cancer; Retinoid X receptor; Testicular receptor 3 |
| Core Tip |
Pancreatic cancer is a devastating disease with well defined genetic alterations made deadly by its subtle nature and the lack of effective drugs. Nuclear receptors (NR) are ligand-regulated transcription factors involved in important cellular functions and tempting targets for drug development. There are now evidences that classical ligand-activated peroxisome proliferator activated receptors, retinoic acid receptors, retinoid X receptors, androgen receptor, estrogen receptors and orphan Nur, chicken ovalbumin upstream promoter transcription factor Ⅱ and liver receptor homologue-1 NR are involved in the pathogenesis of pancreatic cancer. No clinical application of these NR in pancreatic cancer cure is reported but a more comprehensive analysis of NR action could lead to the identification of new treatments for this disease. |
| Publish Date |
2014-09-18 19:50 |
| Citation |
Polvani S, Tarocchi M, Tempesti S, Galli A. Nuclear receptors and pathogenesis of pancreatic cancer. World J Gastroenterol 2014; 20(34): 12062-12081
|
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i34/12062.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i34.12062 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
