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Articles Published Processes
9/18/2014 7:49:00 PM | Browse: 9044 | Download: 1176
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Received |
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2013-11-20 12:12 |
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Peer-Review Started |
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2013-11-21 17:54 |
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To Make the First Decision |
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2013-12-26 10:44 |
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Return for Revision |
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2013-12-26 17:13 |
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Revised |
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Second Decision |
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2014-04-03 10:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-04-03 11:21 |
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Articles in Press |
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2014-05-23 09:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-08-27 09:40 |
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Publish the Manuscript Online |
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2014-09-18 19:50 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Nuclear receptors and pathogenesis of pancreatic cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Simone Polvani, Mirko Tarocchi, Sara Tempesti and Andrea Galli |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fondo per gli Investimenti della Ricerca di Base (FIRB) |
RBAP10MY35_002 |
| Ente Cassa di Risparmio di Firenze |
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| FiorGen ONLUS |
to Galli A |
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| Corresponding Author |
Andrea Galli, Professor, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, 50134 Florence, Italy. a.galli@dfc.unifi.it |
| Key Words |
Peroxisome proliferator activated receptor; Pancreatic intraepithelial neoplasia; COUP-TFⅡ; Nuclear receptors; Orphan nuclear receptor; Nuclear receptors 4A2; Nuclear receptors 2F2; Pancreatic cancer; Retinoid X receptor; Testicular receptor 3 |
| Core Tip |
Pancreatic cancer is a devastating disease with well defined genetic alterations made deadly by its subtle nature and the lack of effective drugs. Nuclear receptors (NR) are ligand-regulated transcription factors involved in important cellular functions and tempting targets for drug development. There are now evidences that classical ligand-activated peroxisome proliferator activated receptors, retinoic acid receptors, retinoid X receptors, androgen receptor, estrogen receptors and orphan Nur, chicken ovalbumin upstream promoter transcription factor Ⅱ and liver receptor homologue-1 NR are involved in the pathogenesis of pancreatic cancer. No clinical application of these NR in pancreatic cancer cure is reported but a more comprehensive analysis of NR action could lead to the identification of new treatments for this disease. |
| Publish Date |
2014-09-18 19:50 |
| Citation |
Polvani S, Tarocchi M, Tempesti S, Galli A. Nuclear receptors and pathogenesis of pancreatic cancer. World J Gastroenterol 2014; 20(34): 12062-12081 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i34/12062.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i34.12062 |
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