Publication Name	World Journal of Gastroenterology
Manuscript ID	7392
Country	Germany

Received	2013-11-16 11:29
Peer-Review Started	2013-11-16 16:40
To Make the First Decision	2013-12-03 19:03
Return for Revision	2013-12-13 15:02
Revised	2013-12-18 16:53
Second Decision	2014-04-29 12:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-29 14:18
Articles in Press	2014-05-23 09:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-11 12:58
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Prognostic relevance of minimal residual disease in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Ulrich Bork, Robert Grützmann, Nuh N Rahbari, Sebastian Schölch, Marius Distler, Christoph Reissfelder, Moritz Koch and Jürgen Weitz
Funding Agency and Grant Number
Corresponding Author	Ulrich Bork, MD, Department of GI, Thoracic and Vascular Surgery, University Hospital Dresden, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany. ulrich.bork@uniklinikum-dresden.de
Key Words	Colorectal cancer; Circulating tumor cells; Disseminated tumor cells; Isolated tumor cells; Micrometastases; Occult disease; Minimal residual disease
Core Tip	Occult disease or minimal residual disease is defined by the presence of tumor cells in the blood, bone marrow or lymph nodes not found in conventional staging procedures. Occult disease in form of circulating tumor cells in the blood, disseminated tumor cells in the bone marrow and micrometastases and isolated tumor cells in the lymph nodes is a prognostic marker for survival in colorectal cancer. Future research should be directed to test the predictive value of occult disease as an additional staging tool to identify high risk patients. The patient group at risk might benefit from additional individualized treatment options and this should be investigated in future clinical trials.
Publish Date	2014-08-18 16:49
Citation	Bork U, Grützmann R, Rahbari NN, Schölch S, Distler M, Reissfelder C, Koch M, Weitz J. Prognostic relevance of minimal residual disease in colorectal cancer. World J Gastroenterol 2014; 20(30): 10296-10304
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10296.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10296

Full Article (PDF)	WJG-20-10296.pdf
Full Article (Word)	WJG-20-10296.doc
Manuscript File	7392-Review.docx
Answering Reviewers	7392-Answering reviewers.pdf
Copyright License Agreement	7392-Copyright assignment.pdf
Peer-review Report	7392-Peer reviews.pdf
Scientific Editor Work List	7392-Scientific editor work list.pdf