Publication Name	World Journal of Gastroenterology
Manuscript ID	7393
Country	Germany

Received	2013-11-16 11:35
Peer-Review Started	2013-11-16 16:32
First Decision by Editorial Office Director
Return for Revision	2013-12-13 14:56
Revised	2014-01-02 21:09
Publication Fee Transferred
Second Decision by Editor	2014-05-14 09:12
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-14 09:39
Articles in Press	2014-05-23 09:53
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-25 17:23
Publish the Manuscript Online	2014-10-16 15:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Topic Highlights
Article Title	Pathology of pancreatic ductal adenocarcinoma: Facts, challenges and future developments
Manuscript Source	Invited Manuscript
All Author List	Irene Esposito, Björn Konukiewitz, Anna Melissa Schlitter and Günter Klöppel
Funding Agency and Grant Number	Funding Agency Grant Number EU COST Action BM1204 EUPancreas
Corresponding Author	Irene Esposito, MD, Institute of Pathology, Technische Universität München, Ismaningerstr 22, 81675 Munich, Germany. esposito@lrz.tu-muenchen.de
Key Words	Pancreatic cancer; R1; Molecular subtypes; Atypical flat lesion; Precursor lesions; Pancreatic ductal adenocarcinoma
Core Tip	Despite recent progresses, pancreatic ductal adenocarcinoma (PDAC) remains a disease with poor prognosis. Pathology has given fundamental contributions to these developments. In particular, precursor lesions have been identified and a model for PDAC development has been proposed and validated by molecular studies, which represent the basis for the identification of biomarkers for early diagnosis. A standardized protocol for the post-operative assessment of prognostic relevant parameters, such as the resection margin status, has been developed and has shown a high degree of interlaboratory reproducibility. Finally, the genome-wide analysis of PDAC has led to the identification of distinct molecular subtypes with different therapy response and clinical courses.
Publish Date	2014-10-16 15:53
Citation	Esposito I, Konukiewitz B, Schlitter AM, Klöppel G. Pathology of pancreatic ductal adenocarcinoma: Facts, challenges and future developments. World J Gastroenterol 2014; 20(38): 13833-13841
URL	http://www.wjgnet.com/1007-9327/full/v20/i38/13833.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i38.13833

Full Article (PDF)	WJG-20-13833.pdf
Full Article (Word)	WJG-20-13833.doc
Manuscript File	7393-Review.docx
Answering Reviewers	7393-Answering reviewers.pdf
Copyright License Agreement	7393-Copyright assignment.pdf
Peer-review Report	7393-Peer reviews.pdf
Scientific Editor Work List	7393-Scientific editor work list.pdf