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Articles Published Processes
5/20/2022 2:41:53 AM | Browse: 783 | Download: 1355
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Received |
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2021-12-14 09:34 |
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Peer-Review Started |
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2021-12-14 09:35 |
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First Decision by Editorial Office Director |
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2022-02-15 00:52 |
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Return for Revision |
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2022-02-15 00:52 |
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Revised |
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2022-03-03 14:38 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-04-27 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-04-28 02:32 |
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Articles in Press |
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2022-04-28 02:32 |
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Edit the Manuscript by Language Editor |
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2022-04-25 14:24 |
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Typeset the Manuscript |
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2022-05-18 08:38 |
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Publish the Manuscript Online |
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2022-05-20 02:41 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Review |
| Article Title |
Severe acute respiratory syndrome coronavirus 2 infection: Role of interleukin-6 and the inflammatory cascade
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mohaddeseh Bahmani, Rojin Chegini, Elham Ghanbari, Elham Sheykhsaran, Parisa Shiri Aghbash, Hamed Ebrahimzadeh Leylabadlo, Ehsan Moradian, Amir Masoud Kazemzadeh Houjaghan and Hossein Bannazadeh Baghi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hossein Bannazadeh Baghi, PhD, Assistant Professor, Department of Virology, Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, NA, Tabriz 15731, Iran. hbannazadeh@tbzmed.ac.ir |
| Key Words |
Anti-interleukin-6; COVID-19; Inflammation; Interleukin-6; Interleukin-6 receptor; SARS-CoV-2 |
| Core Tip |
One of the most considered treatment strategies for severe acute respiratory syndrome coronavirus 2 is targeting the immune response and pro-inflammatory cytokines such as interleukin (IL)-6. Patients with severe acute respiratory syndrome coronavirus 2 show elevated levels of IL-6, which is related to disease severity. Current studies have shown that IL-6 blockade by anti-IL-6 or its receptor antibodies such as tocilizumab is beneficial in severe cases and may reduce the mortality rate. Moreover, the combination of anti-inflammatory agents is more effective than single therapy. |
| Publish Date |
2022-05-20 02:41 |
| Citation |
Bahmani M, Chegini R, Ghanbari E, Sheykhsaran E, Shiri Aghbash P, Leylabadlo HE, Moradian E, Kazemzadeh Houjaghan AM, Bannazadeh Baghi H. Severe acute respiratory syndrome coronavirus 2 infection: Role of interleukin-6 and the inflammatory cascade. World J Virol 2022; 11(3): 113-128
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| URL |
https://www.wjgnet.com/2220-3249/full/v11/i3/113.htm |
| DOI |
https://dx.doi.org/10.5501/wjv.v11.i3.113 |
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