Publication Name	World Journal of Gastroenterology
Manuscript ID	74137
Country	Argentina

Received	2022-01-13 14:25
Peer-Review Started	2022-01-13 14:26
To Make the First Decision
Return for Revision	2022-03-08 20:00
Revised	2022-03-21 18:21
Second Decision	2022-05-26 02:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-28 03:28
Articles in Press	2022-05-28 03:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-13 08:42
Typeset the Manuscript	2022-06-30 06:48
Publish the Manuscript Online	2022-07-13 07:31

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide
Manuscript Source	Invited Manuscript
All Author List	María Belén Novoa Díaz, Pedro Carriere, Graciela Gigola, Ariel Osvaldo Zwenger, Natalia Calvo and Claudia Gentili
ORCID	Author(s) ORCID Number María Belén Novoa Díaz http://orcid.org/0000-0002-6684-4076 Pedro Carriere http://orcid.org/0000-0002-5751-8850 Graciela Gigola http://orcid.org/0000-0001-7362-3178 Ariel Osvaldo Zwenger http://orcid.org/0000-0002-4407-5413 Natalia Calvo http://orcid.org/0000-0003-3627-6749 Claudia Gentili http://orcid.org/0000-0002-9957-7824
Funding Agency and Grant Number	Funding Agency Grant Number Agencia Nacional de Promoción Científica y Tecnológica PICT-2013-1441 Consejo Nacional de Investigaciones Científicas y Técnicas PIP11220150100350 Instituto Nacional del Cáncer 12002-4395-14-1, RESOL-493/14 Instituto Nacional del Cáncer 2016-2017, RESOL-2016-1006-E-APN-MS Universidad Nacional del Sur PGI: 24/B230; PGI: 24/B303 Fundación Alberto J. Roemmers, Argentina
Corresponding Author	Claudia Gentili, PhD, Professor, Research Scientist, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)- INBIOSUR (CONICET-UNS), 670 San Juan, Bahía Blanca 8000, Buenos Aires, Argentina. cgentili@criba.edu.ar
Key Words	PTHrP; MET receptor tyrosine kinase; Parathyroid hormone receptor type 1; Colorectal cancer; Drug resistance
Core Tip	Colorectal cancer (CRC) is one of the leading causes of cancer death, and chemoresistance is common in the treatment of CRC patients. Parathyroid hormone-related peptide (PTHrP) and the receptor tyrosine kinase Met are involved in the aggressive behavior of CRC cells. However, to date it is unknown whether PTHrP and Met are related to promoting events associated with the progression and chemoresistance of CRC. Herein we showed, for the first time, a PTHrP/Met axis that could have a positive impact on the knowledge of CRC biology and on the development of new targeted therapies.
Publish Date	2022-07-13 07:31
Citation	Novoa Díaz MB, Carriere P, Gigola G, Zwenger AO, Calvo N, Gentili C. Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide. World J Gastroenterol 2022; 28(26): 3177-3200
URL	https://www.wjgnet.com/1007-9327/full/v28/i26/3177.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i26.3177

Full Article (PDF)	WJG-28-3177.pdf
Full Article (Word)	WJG-28-3177.docx
The ARRIVE Guidelines	74137-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	74137_Auto_Edited-YLC-Wang TQ-LS.docx
Answering Reviewers	74137-Answering reviewers.pdf
Audio Core Tip	74137-Audio core tip.mpeg
Biostatistics Review Certificate	74137-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	74137-Conflict-of-interest statement.pdf
Copyright License Agreement	74137-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	74137-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	74137-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	74137-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	74137-Language certificate.pdf
Journal Editor-in-Chief Review Report	74137-Peer-review(s).pdf
Scientific Misconduct Check	74137-Bing-Chen YL-2.png
Scientific Editor Work List	74137-Scientific editor work list.pdf