| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
María Belén Novoa Díaz, Pedro Carriere, Graciela Gigola, Ariel Osvaldo Zwenger, Natalia Calvo and Claudia Gentili |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Agencia Nacional de Promoción Científica y Tecnológica |
PICT-2013-1441 |
| Consejo Nacional de Investigaciones Científicas y Técnicas |
PIP11220150100350 |
| Instituto Nacional del Cáncer |
12002-4395-14-1, RESOL-493/14 |
| Instituto Nacional del Cáncer |
2016-2017, RESOL-2016-1006-E-APN-MS |
| Universidad Nacional del Sur |
PGI: 24/B230; PGI: 24/B303 |
| Fundación Alberto J. Roemmers, Argentina |
|
|
| Corresponding Author |
Claudia Gentili, PhD, Professor, Research Scientist, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)- INBIOSUR (CONICET-UNS), 670 San Juan, Bahía Blanca 8000, Buenos Aires, Argentina. cgentili@criba.edu.ar |
| Key Words |
PTHrP; MET receptor tyrosine kinase; Parathyroid hormone receptor type 1; Colorectal cancer; Drug resistance |
| Core Tip |
Colorectal cancer (CRC) is one of the leading causes of cancer death, and chemoresistance is common in the treatment of CRC patients. Parathyroid hormone-related peptide (PTHrP) and the receptor tyrosine kinase Met are involved in the aggressive behavior of CRC cells. However, to date it is unknown whether PTHrP and Met are related to promoting events associated with the progression and chemoresistance of CRC. Herein we showed, for the first time, a PTHrP/Met axis that could have a positive impact on the knowledge of CRC biology and on the development of new targeted therapies. |
| Publish Date |
2022-07-13 07:31 |
| Citation |
Novoa Díaz MB, Carriere P, Gigola G, Zwenger AO, Calvo N, Gentili C. Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide. World J Gastroenterol 2022; 28(26): 3177-3200 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i26/3177.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i26.3177 |
