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Articles Published Processes
7/5/2022 1:22:30 AM | Browse: 289 | Download: 781
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Received |
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2021-12-18 13:52 |
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Peer-Review Started |
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2021-12-18 13:53 |
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To Make the First Decision |
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Return for Revision |
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2022-01-25 08:38 |
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Revised |
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2022-02-04 14:17 |
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Second Decision |
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2022-05-26 02:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-05-28 06:48 |
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Articles in Press |
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2022-05-28 06:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-05-06 13:25 |
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Typeset the Manuscript |
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2022-06-26 15:30 |
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Publish the Manuscript Online |
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2022-07-05 01:22 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Obstetrics & Gynecology |
| Manuscript Type |
Case Report |
| Article Title |
MutL homolog 1 germline mutation c.(453+1_454-1)_(545+1_546-1)del identified in lynch syndrome: A case report and review of literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi-Wen Zhang, Zan-Hui Jia, Li-Ping Zhao, Yi-Shi Wu, Man-Hua Cui, Yan Jia and Tian-Min Xu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Man-Hua Cui, MD, PhD, Chief Doctor, Department of Gynecology, The Second Hospital of Jilin University, No. 218 Ziqiang Road, Changchun 130000, Jilin Province, China. cuimh@jlu.edu.cn |
| Key Words |
Lynch syndrome; Colorectal cancer; Endometrial cancer; MLH1 gene; Gene testing; Case report |
| Core Tip |
Lynch syndrome (LS) is an autosomal dominant hereditary disorder because of germline mutations in DNA mismatch repair genes, such as MutL homolog 1 (MLH1) gene, PMS1 homolog 2 gene, MutS homolog 2 gene, and MutS homolog 6 gene, which make the patient more susceptible to other malignancies. In Chinese, MLH1 germline mutation c.(453+1_454-1)_(545+1_546-1)del-induced LS has been infrequently reported. In this paper, we report a rare LS patient with colorectal and endometrioid adenocarcinoma. The genetic panel sequencing showed a novel pathogenic germline mutation in MLH1, c.(453+1_454-1)_(545+1_546-1)del, for LS. |
| Publish Date |
2022-07-05 01:22 |
| Citation |
Zhang XW, Jia ZH, Zhao LP, Wu YS, Cui MH, Jia Y, Xu TM. MutL homolog 1 germline mutation c.(453+1_454-1)_(545+1_546-1)del identified in lynch syndrome: A case report and review of literature. World J Clin Cases 2022; 10(20): 7105-7115 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i20/7105.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i20.7105 |
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