BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
7/5/2022 1:22:30 AM | Browse: 188 | Download: 437
Publication Name World Journal of Clinical Cases
Manuscript ID 74260
Country/Territory China
Received
2021-12-18 13:52
Peer-Review Started
2021-12-18 13:53
To Make the First Decision
Return for Revision
2022-01-25 08:38
Revised
2022-02-04 14:17
Second Decision
2022-05-26 02:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-28 06:48
Articles in Press
2022-05-28 06:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-05-06 13:25
Typeset the Manuscript
2022-06-26 15:30
Publish the Manuscript Online
2022-07-05 01:22
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Obstetrics & Gynecology
Manuscript Type Case Report
Article Title MutL homolog 1 germline mutation c.(453+1_454-1)_(545+1_546-1)del identified in lynch syndrome: A case report and review of literature
Manuscript Source Unsolicited Manuscript
All Author List Xi-Wen Zhang, Zan-Hui Jia, Li-Ping Zhao, Yi-Shi Wu, Man-Hua Cui, Yan Jia and Tian-Min Xu
ORCID
Author(s) ORCID Number
Xi-Wen Zhang http://orcid.org/0000-0002-7092-6461
Zan-Hui Jia http://orcid.org/0000-0001-7105-7563
Li-Ping Zhao http://orcid.org/0000-0001-5684-7022
Yi-Shi Wu http://orcid.org/0000-0002-8129-0323
Man-Hua Cui http://orcid.org/0000-0001-7694-6917
Yan Jia http://orcid.org/0000-0002-3704-4977
Tian-Min Xu http://orcid.org/0000-0002-1219-061X
Funding Agency and Grant Number
Corresponding Author Man-Hua Cui, MD, PhD, Chief Doctor, Department of Gynecology, The Second Hospital of Jilin University, No. 218 Ziqiang Road, Changchun 130000, Jilin Province, China. cuimh@jlu.edu.cn
Key Words Lynch syndrome; Colorectal cancer; Endometrial cancer; MLH1 gene; Gene testing; Case report
Core Tip Lynch syndrome (LS) is an autosomal dominant hereditary disorder because of germline mutations in DNA mismatch repair genes, such as MutL homolog 1 (MLH1) gene, PMS1 homolog 2 gene, MutS homolog 2 gene, and MutS homolog 6 gene, which make the patient more susceptible to other malignancies. In Chinese, MLH1 germline mutation c.(453+1_454-1)_(545+1_546-1)del-induced LS has been infrequently reported. In this paper, we report a rare LS patient with colorectal and endometrioid adenocarcinoma. The genetic panel sequencing showed a novel pathogenic germline mutation in MLH1, c.(453+1_454-1)_(545+1_546-1)del, for LS.
Publish Date 2022-07-05 01:22
Citation Zhang XW, Jia ZH, Zhao LP, Wu YS, Cui MH, Jia Y, Xu TM. MutL homolog 1 germline mutation c.(453+1_454-1)_(545+1_546-1)del identified in lynch syndrome: A case report and review of literature. World J Clin Cases 2022; 10(20): 7105-7115
URL https://www.wjgnet.com/2307-8960/full/v10/i20/7105.htm
DOI https://dx.doi.org/10.12998/wjcc.v10.i20.7105
Full Article (PDF) WJCC-10-7105.pdf
Full Article (Word) WJCC-10-7105.docx
Manuscript File 74260_Auto_Edited-WangTQ-CKL-LS.docx
Answering Reviewers 74260-Answering reviewers.pdf
Audio Core Tip 74260-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 74260-Conflict-of-interest statement.pdf
Copyright License Agreement 74260-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s) 74260-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 74260-Language certificate.pdf
Peer-review Report 74260-Peer-review(s).pdf
Scientific Misconduct Check 74260-Bing-Chang KL-2.jpg
Scientific Editor Work List 74260-Scientific editor work list.pdf