Publication Name	World Journal of Gastroenterology
Manuscript ID	7436
Country	Italy

Received	2013-11-18 10:06
Peer-Review Started	2013-11-18 19:08
To Make the First Decision	2014-01-09 16:47
Return for Revision	2014-01-12 17:45
Revised
Second Decision	2014-03-19 13:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-19 14:59
Articles in Press	2014-05-23 11:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-02 19:12
Typeset the Manuscript	2014-08-08 09:09
Publish the Manuscript Online	2014-08-20 18:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Topic Highlights
Article Title	Genetic predisposition to pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Paola Ghiorzo
Funding Agency and Grant Number	Funding Agency Grant Number Università degli Studi di Genova Progetti di Ricerca di Ateneo PRA 2012-2013 IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 5 per 1000 per la Ricerca Corrente
Corresponding Author	Paola Ghiorzo, PhD, Department of Internal Medicine and Medical Specialties, University of Genoa and IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazioanle per la Ricerca sul Cancro, V.le Benedetto XV 6, 16132 Genoa, Italy. paola.ghiorzo@unige.it
Key Words	pancreatic adenocarcinoma; susceptibility genes; CDKN2A; melanoma; hereditary cancer syndromes
Core Tip	Pancreatic adenocarcinoma is the most deadly of the common cancers. Identifying families with hereditary pancreatic cancer can aid appropriate selection of individuals who are at high risk and are good candidates for prevention and screening programs. Although genetic predisposition to pancreatic cancer remains largely unexplained, next-generation sequencing is likely to provide important insights. Candidate genes have been described and patients considered for screening protocols should first be tested for germline mutations in these genes. In specific pancreatic cancer populations, including Italy, hereditary cancer predisposition genes such as CDKN2A also explain a considerable fraction of hereditary pancreatic cancers.
Publish Date	2014-08-20 18:38
Citation	Ghiorzo P. Genetic predisposition to pancreatic cancer. World J Gastroenterol 2014; 20(31): 10778-10789
URL	http://www.wjgnet.com/1007-9327/full/v20/i31/10778.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i31.10778

Full Article (PDF)	WJG-20-10778.pdf
Full Article (Word)	WJG-20-10778.doc
Manuscript File	7436-Review.docx
Answering Reviewers	7436-Answering reviewers.pdf
Copyright License Agreement	7436-Copyright assignment.pdf
Peer-review Report	7436-Peer review(s).pdf
Scientific Editor Work List	7436-Scientific editor work list.doc