| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Peroxisome proliferator-activated receptor-alpha activation and dipeptidyl peptidase-4 inhibition target dysbiosis to treat fatty liver in obese mice
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Flavia Maria Silva-Veiga, Carolline Santos Miranda, Isabela Macedo Lopes Vasques-Monteiro, Henrique Souza-Tavares, Fabiane Ferreira Martins, Julio Beltrame Daleprane and Vanessa Souza-Mello |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil |
CAPES–Finance Code 001 |
| Fundação Carlos Chagas Filho de Amparo à Pesquisa do Rio de Janeiro (FAPERJ) to Souza-Mello V |
E-26/202.657/2018 |
| Fundação Carlos Chagas Filho de Amparo à Pesquisa do Rio de Janeiro (FAPERJ) to Souza-Mello V |
E-26/010.002136/2019 |
| The corresponding author is supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
303785/2020-9 |
|
| Corresponding Author |
Vanessa Souza-Mello, PhD, Associate Professor, Department of Anatomy, Institute of Biology, State University of Rio de Janeiro, Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Blvd. 28 de Setembro 87, Fundos, Vila Isabel, Rio de Janeiro 20551-030, Brazil. souzamello.uerj@gmail.com |
| Key Words |
Nonalcoholic fatty liver disease; High-fat diet; Peroxisome proliferator-activated receptor-alpha; Dipeptidyl-peptidase-4-inhibitor; Dysbiosis; Inflammation |
| Core Tip |
Chronic high-fat diet (HF) intake alters the phylogenetic microbiota composition, sending harmful proinflammatory signals to the liver that elicit nonalcoholic fatty liver disease (NAFLD) in mice. Here, we treated HF diet-induced obese mice with a peroxisome proliferator-activated receptor-alpha agonist (WY14643), a dipeptidyl-peptidase-4 inhibitor (linagliptin), or their combination, focusing on gut–liver axis modulation. The treatments rescued gut dysbiosis and endotoxemia due to increased tight junction gene expression, mucin production, and numerical density of goblet cells in the intestinal crypts. Treated mice benefited from downregulated Tlr4, Cd206, and Nlrp3, alleviating fatty liver through anti-inflammatory signals such as increased IL-10 and IL-13. |
| Publish Date |
2022-04-29 06:42 |
| Citation |
Silva-Veiga FM, Miranda CS, Vasques-Monteiro IML, Souza-Tavares H, Martins FF, Daleprane JB, Souza-Mello V. Peroxisome proliferator-activated receptor-alpha activation and dipeptidyl peptidase-4 inhibition target dysbiosis to treat fatty liver in obese mice. World J Gastroenterol 2022; 28(17): 1814-1829 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i17/1814.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i17.1814 |
