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Articles Published Processes
7/22/2022 7:03:59 AM | Browse: 316 | Download: 589
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Received |
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2022-02-11 01:43 |
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Peer-Review Started |
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2022-02-11 01:46 |
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To Make the First Decision |
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Return for Revision |
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2022-05-30 00:52 |
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Revised |
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2022-06-02 16:33 |
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Second Decision |
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2022-06-20 03:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-06-26 22:40 |
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Articles in Press |
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2022-06-26 22:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-06-30 08:36 |
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Publish the Manuscript Online |
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2022-07-22 07:03 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Early detection of circulating tumor DNA and successful treatment with osimertinib in thr790met-positive leptomeningeal metastatic lung cancer: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Qing Xu, Ying-Jin Wang, Sheng-Li Shen, Yao Wu and Hong-Zhou Duan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hong-Zhou Duan, Doctor, PhD, Chief Doctor, Department of Neurosurgery, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing 100034, Beijing, Djibouti. duanhongzhou@126.com |
| Key Words |
Non-small cell lung cancer; Epidermal growth factor receptor mutation; Circulating tumor DNA detection; Leptomeningeal carcinomatosis; Osimertinib; Case report |
| Core Tip |
Examination of circulating tumor DNA in cell-free cell-free cerebrospinal fluid (CSF) has been shown to be useful for detecting the genomic mutations of tumors in the central nervous system, and osimertinib is considered to be a recent standardized treatment for epidermal growth factor receptor (EGFR) Thr790Met-mutant non-small-cell lung cancer (NSCLC). Hence, we report a patient with EGFR Thr790Met-mutant NSCLC with meningeal carcinomatosis and resistance to gefitinib and propose that the positive findings of CSF circulating tumor DNA as a liquid biopsy technology based on the detection of cancer-associated gene mutations that may appear earlier than the imaging and CSF findings and thus be helpful for therapy. |
| Publish Date |
2022-07-22 07:03 |
| Citation |
Xu L, Wang Y, Shen S, Wu Y, Duan H. Early detection of circulating tumor DNA and successful treatment with osimertinib in thr790met-positive leptomeningeal metastatic lung cancer: A case report. World J Clin Cases 2022; 10(22): 7968-7972 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i22/7968.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i22.7968 |
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