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Articles Published Processes
7/18/2022 9:47:46 AM | Browse: 480 | Download: 1142
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Received |
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2022-01-03 22:56 |
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Peer-Review Started |
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2022-01-03 22:57 |
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To Make the First Decision |
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Return for Revision |
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2022-01-23 05:50 |
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Revised |
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2022-01-27 23:16 |
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Second Decision |
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2022-06-21 03:10 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-06-26 06:39 |
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Articles in Press |
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2022-06-26 06:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-07 08:52 |
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Publish the Manuscript Online |
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2022-07-18 09:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Regulatory T cells and their associated factors in hepatocellular carcinoma development and therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chun-Ye Zhang, Shuai Liu and Ming Yang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ming Yang, DVM, PhD, Postdoctoral Fellow, Department of Surgery, University of Missouri, Room 2203，NexGen Precision Building, 1030 Hitt Street, Columbia, MO 65211, United States. yangmin@health.missouri.edu |
| Key Words |
Hepatocellular carcinoma; Regulatory T cells; Alcoholic fatty liver disease; Non-alcoholic fatty liver disease; Treatment; Clinical trials |
| Core Tip |
Liver cancer is the third leading cause of cancer-related death worldwide. Hepatocellular carcinoma (HCC) is the primary type of liver cancer. Factors, including carcinogenic infection of hepatitis viruses, alcohol abuse, and non-alcoholic fatty liver disease (NAFLD), can induce HCC initiation and promote HCC progression. The prevalence of NAFLD accompanying the increased incidence of obesity and type 2 diabetes becomes the most increasing factor causing HCC worldwide. However, the benefit of current therapeutic options is still limited. Intrahepatic immunity plays critically important roles in HCC initiation, development, and progression. Regulatory T cells (Tregs) and their associated factors such as metabolites and secreting cytokines mediate the immune tolerance of the tumor microenvironment in HCC. Therefore, targeting Tregs and blocking their mediated factors may prevent HCC progression. A better understanding of the role of Tregs in intrahepatic immunity is helpful to develop novel HCC treatment options. |
| Publish Date |
2022-07-18 09:47 |
| Citation |
Zhang CY, Liu S, Yang M. Regulatory T cells and their associated factors in hepatocellular carcinoma development and therapy. World J Gastroenterol 2022; 28(27): 3346-3358 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i27/3346.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i27.3346 |
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