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Articles Published Processes
7/26/2022 11:15:04 AM | Browse: 322 | Download: 885
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Received |
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2022-03-04 07:02 |
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Peer-Review Started |
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2022-03-04 07:04 |
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To Make the First Decision |
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Return for Revision |
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2022-04-19 02:18 |
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Revised |
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2022-05-19 07:00 |
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Second Decision |
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2022-06-24 03:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-06-24 22:41 |
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Articles in Press |
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2022-06-24 22:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-19 10:05 |
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Publish the Manuscript Online |
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2022-07-26 11:15 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Developmental Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ramya Lakshmi Rajendran, Prakash Gangadaran, Mi Hee Kwack, Ji Min Oh, Chae Moon Hong, Young Kwan Sung, Jaetae Lee and Byeong-Cheol Ahn |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program through the National Research Foundation of Korea (NRF), Funded By the Ministry of Education |
NRF-2019R1I1A1A01061296 |
| Basic Science Research Program through the National Research Foundation of Korea (NRF), Funded By the Ministry of Education |
NRF-2021R1I1A1A01040732 |
| Korea Health Technology R & D Project through the Korea Health Industry Development Institute, Funded By the Ministry of Health & Welfare, Republic of Korea |
HI15C0001 |
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| Corresponding Author |
Byeong-Cheol Ahn, MD, PhD, Professor, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, No. 680 Gukchaebosangro, Junggu, Daegu 41944, South Korea. abc2000@knu.ac.kr |
| Key Words |
Mesenchymal stem cells; Extracellular vesicles; Hair growth; Dermal papillae; Outer root sheath cells |
| Core Tip |
Alopecia is a common medical problem affecting both males and females. This study found that Wnt3a is enriched in human mesenchymal stem cell-derived extracellular vesicles (hMSC-EVs) and associated with their EVs’ surface. hMSC-EVs associated wnt3a can activate the Wnt/β-catenin signaling in recipient dermal papillae cells. hMSC-EVs activate keratin differentiation in recipient outer root sheath cells and increase hair shaft elongation. These findings open up for new hair growth treatment strategies to be developed for alopecia. |
| Publish Date |
2022-07-26 11:15 |
| Citation |
Rajendran RL, Gangadaran P, Kwack MH, Oh JM, Hong CM, Sung YK, Lee J, Ahn BC. Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles. World J Stem Cells 2022; 14(7): 527-538 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i7/527.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i7.527 |
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