| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Murine model to study brain, behavior and immunity during hepatic encephalopathy
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Lindisley Ferreira Gomides, Pedro Elias Marques, Bruno Engler Faleiros, Rafaela Vaz Pereira, Sylvia Stella Amaral, Thais Reis Lage, Gustavo Henrique Souza Resende, Patricia Alves Maia Guidine, Giselle Foureaux, Fabíola Mara Ribeiro, Fabiana Paiva Martins, Marco Antônio Peliky Fontes, Anderson José Ferreira, Remo Castro Russo, Mauro Martins Teixeira, Márcio Flávio Moraes, Antonio Lúcio Teixeira and Gustavo Batista Menezes |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Gustavo Batista Menezes, PhD, Laboratório de Imunobiofotônica, Department of Morphology, ICB, UFMG, Av. Antonio Carlos, 6627 - Pampulha, Belo Horizonte 31270-901, Brazil. menezesgb@ufmg.br |
| Key Words |
Hepatic encephalopathy; Liver injury; Thioacetamide; Neurological dysfunction; Neuropsychomotor abnormalities; Intracranial hypertension; Cerebral herniation |
| Core Tip |
The study of hepatic encephalopathy is crucial for development of new therapies but has been dampened by the absence of murine models resembling the disease in patients. We showed that sequential thioacetamide injections cause extensive liver injury in mice, leading to increased ammonia levels, electroencephalography alterations and brain edema. In line with this, mice presented with poor psychomotor activity and survival rate. Liver injury and brain function impairment by thioacetamide resulted in systemic alterations such as coagulopathy, hemodynamic instability and lung inflammation, consistent with multiple organ failure. Therefore, this alternative model may provide tools for new therapeutic insights for hepatic encephalopathy. |
| Publish Date |
2014-05-20 15:05 |
| Citation |
Gomides LF, Marques PE, Faleiros BE, Pereira RV, Amaral SS, Lage TR, Resende GHS, Guidine PAM, Foureaux G, Ribeiro FM, Martins FP, Fontes MAP, Ferreira AJ, Russo RC, Teixeira MM, Moraes MF, Teixeira AL, Menezes GB. Murine model to study brain, behavior and immunity during hepatic encephalopathy. World J Hepatol 2014; 6(4): 243-250 |
| URL |
http://www.wjgnet.com/1948-5182/full/v6/i4/243.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v6.i4.243 |
