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Articles Published Processes
9/9/2022 12:48:14 PM | Browse: 332 | Download: 814
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Received |
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2022-03-18 22:41 |
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Peer-Review Started |
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2022-03-18 22:43 |
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To Make the First Decision |
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Return for Revision |
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2022-04-17 03:20 |
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Revised |
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2022-05-05 21:00 |
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Second Decision |
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2022-06-29 03:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-07-06 14:47 |
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Articles in Press |
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2022-07-06 14:47 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-08-04 17:23 |
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Typeset the Manuscript |
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2022-08-24 00:28 |
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Publish the Manuscript Online |
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2022-09-09 12:48 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Immunotherapy for nonalcoholic fatty liver disease-related hepatocellular carcinoma: Lights and shadows
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Federico Costante, Carlo Airola, Francesco Santopaolo, Antonio Gasbarrini, Maurizio Pompili and Francesca Romana Ponziani |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Francesca Romana Ponziani, MD, PhD, Additional Professor, Internal Medicine and Gastroenterology-Hepatology Unit, Fondazione Policlinico Univeresitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Roma 00168, Italy. francesca.ponziani@gmail.com |
| Key Words |
Hepatocellular carcinoma; Immunotherapy; Liver cancer; Nonalcoholic fatty liver disease; Metabolic dysfunction-associated fatty liver disease; Obesity |
| Core Tip |
Complex interactions involving the immune system, angiogenesis and inflammation are associated with the pathogenesis of hepatocellular carcinoma. Recent reviews suggested lower efficacy of immunotherapy in patients with non-viral hepatocellular carcinoma. This calls into question the need to stratify patients to maximize the effectiveness of immunotherapeutic agents. In this study, we provided the latest report on the tumor microenvironment structure and its implications in response to immunotherapy in nonalcoholic fatty liver disease-related hepatocellular carcinoma and also discussed the efficacy of first-line systemic treatment in this patient population. |
| Publish Date |
2022-09-09 12:48 |
| Citation |
Costante F, Airola C, Santopaolo F, Gasbarrini A, Pompili M, Ponziani FR. Immunotherapy for nonalcoholic fatty liver disease-related hepatocellular carcinoma: Lights and shadows. World J Gastrointest Oncol 2022; 14(9): 1622-1636 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i9/1622.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i9.1622 |
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