| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Thais Maloberti, Antonio De Leo, Viviana Sanza, Elisa Gruppioni, Annalisa Altimari, Mattia Riefolo, Michela Visani, Deborah Malvi, Antonia D'Errico, Giovanni Tallini, Francesco Vasuri and Dario de Biase |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dario de Biase, MSc, PhD, Associate Professor, Department of Pharmacy and biotechnology (FaBiT), University of Bologna, viale Ercolani 4/2, S.Orsola Hospital, Bologna 40138, Italy. dario.debiase@unibo.it |
| Key Words |
Hepatocarcinoma; Mutation; Next-generation sequencing; Review; TP53; CTNNB1; TERT |
| Core Tip |
The molecular mechanisms that drive hepatocellular carcinoma tumorigenesis are extremely complex, and a univocal classification based on molecular features has not been defined. In the age of precision medicine, the study of hepatocellular carcinoma mutations is still a field worth investigating. Based on this, we wanted to analyze the possible correlations between molecular alterations and pathological features. Considering both the literature data and our personal experience, about 80% of hepatocellular carcinomas harbor mutations in at least one of the following genes, TERT, TP53, or CTNNB1, with different biological and clinical implications. |
| Publish Date |
2022-07-04 12:30 |
| Citation |
Maloberti T, De Leo A, Sanza V, Gruppioni E, Altimari A, Riefolo M, Visani M, Malvi D, D'Errico A, Tallini G, Vasuri F, de Biase D. Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center. World J Gastroenterol 2022; 28(25): 2854-2866 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i25/2854.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i25.2854 |
