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Articles Published Processes
9/27/2022 1:00:17 PM | Browse: 420 | Download: 1527
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Received |
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2022-01-25 12:41 |
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Peer-Review Started |
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2022-01-25 12:42 |
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First Decision by Editorial Office Director |
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2022-03-23 03:00 |
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Return for Revision |
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2022-03-23 03:00 |
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Revised |
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2022-03-25 15:31 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-08-18 03:13 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-08-21 23:00 |
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Articles in Press |
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2022-08-21 23:00 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-09-07 03:52 |
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Publish the Manuscript Online |
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2022-09-27 13:00 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Respiratory System |
| Manuscript Type |
Case Report |
| Article Title |
Successful treatment of disseminated nocardiosis diagnosed by metagenomic next-generation sequencing: A case report and review of literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting Li, Yi-Xin Chen, Jia-Jia Lin, Wei-Xian Lin, Wei-Zhen Zhang, Hang-Ming Dong, Shao-Xi Cai and Ying Meng |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ying Meng, Doctor, Chief Doctor, Department of Respiratory and Critical Care Medicine, Nanfang Hospital，Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou 510515, Guangdong Province, China. nfyymengy@163.com |
| Key Words |
Disseminated nocardiosis; Metagenomic next-generation sequencing; Linezolid; Thrombocytopenia; Case report |
| Core Tip |
Early detection of Nocardia paucivorans can optimize antibiotic management, shorten hospital stays and improve survival rates. We report rapid detection of N. paucivorans by metagenomic next-generation sequencing (mNGS) of BALF. The patient was treated with trimethoprim–sulfamethoxazole (TMP-SMZ) and linezolid by implementation of individual dose adjustment based on serum concentration and thrombocytopenia and leukopenia, then replaced by TMP-SMZ and ceftriaxone or minocycline. This case suggests that mNGS is a convenient and efficient technique for detecting Nocardia, especially suitable for rare, novel and atypical etiologies of complicated infectious diseases. Linezolid may be an important alternative in disseminated nocardiosis. |
| Publish Date |
2022-09-27 13:00 |
| Citation |
Li T, Chen YX, Lin JJ, Lin WX, Zhang WZ, Dong HM, Cai SX, MENG Y. Successful treatment of disseminated nocardiosis diagnosed by metagenomic next-generation sequencing: A case report and review of literature. World J Clin Cases 2022; 10(28): 10120-10129
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| URL |
https://www.wjgnet.com/2307-8960/full/v10/i28/10120.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i28.10120 |
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