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Articles Published Processes
8/16/2022 11:59:52 AM | Browse: 764 | Download: 1648
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Received |
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2022-01-25 18:38 |
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Peer-Review Started |
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2022-01-25 18:39 |
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First Decision by Editorial Office Director |
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2022-04-10 21:33 |
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Return for Revision |
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2022-04-10 21:33 |
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Revised |
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2022-04-19 14:28 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-07-18 03:04 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-07-22 03:18 |
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Articles in Press |
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2022-07-22 03:18 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-25 03:35 |
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Publish the Manuscript Online |
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2022-08-16 11:59 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Evidence-based pathogenesis and treatment of ulcerative colitis: A causal role for colonic epithelial hydrogen peroxide
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jay Pravda |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jay Pravda, MD, Research Scientist, Senior Researcher, Disease Pathogenesis, Inflammatory Disease Research Centre, 4371 Northlake Blvd No. 247, Palm Beach Gardens, FL 33410, United States. jay.pravda@protonmail.com |
| Key Words |
Ulcerative colitis; Pathogenesis, Treatment; Hydrogen peroxide |
| Core Tip |
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that has resisted all efforts to uncover its cause and cure. However, an evidence-based systems medicine approach has provided compelling evidence that the secretion of hydrogen peroxide (H2O2) from colonic epithelial cells is the etiological agent responsible for this debilitating illness. H2O2 is a highly potent chemotactic agent that can attract neutrophils into the colonic epithelium, and significantly elevated production of H2O2 has been documented in the non-inflamed colonic epithelium of individuals with UC. Treatment to normalize colonic H2O2 leads to long-lasting histologic remission. |
| Publish Date |
2022-08-16 11:59 |
| Citation |
Pravda J. Evidence-based pathogenesis and treatment of ulcerative colitis: a causal role for colonic epithelial hydrogen peroxide. World J Gastroenterol 2022;28(31): 4263-4298 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i31/4263.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i31.4263 |
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