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8/16/2022 11:59:52 AM | Browse: 316 | Download: 687
Publication Name World Journal of Gastroenterology
Manuscript ID 75384
Country/Territory United States
Received
2022-01-25 18:38
Peer-Review Started
2022-01-25 18:39
To Make the First Decision
Return for Revision
2022-04-10 21:33
Revised
2022-04-19 14:28
Second Decision
2022-07-18 03:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-22 03:18
Articles in Press
2022-07-22 03:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-25 03:35
Publish the Manuscript Online
2022-08-16 11:59
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Evidence-based pathogenesis and treatment of ulcerative colitis: A causal role for colonic epithelial hydrogen peroxide
Manuscript Source Unsolicited Manuscript
All Author List Jay Pravda
ORCID
Author(s) ORCID Number
Jay Pravda http://orcid.org/0000-0001-5737-5506
Funding Agency and Grant Number
Corresponding Author Jay Pravda, MD, Research Scientist, Senior Researcher, Disease Pathogenesis, Inflammatory Disease Research Centre, 4371 Northlake Blvd No. 247, Palm Beach Gardens, FL 33410, United States. jay.pravda@protonmail.com
Key Words Ulcerative colitis; Pathogenesis, Treatment; Hydrogen peroxide
Core Tip Ulcerative colitis (UC) is a chronic inflammatory bowel disease that has resisted all efforts to uncover its cause and cure. However, an evidence-based systems medicine approach has provided compelling evidence that the secretion of hydrogen peroxide (H2O2) from colonic epithelial cells is the etiological agent responsible for this debilitating illness. H2O2 is a highly potent chemotactic agent that can attract neutrophils into the colonic epithelium, and significantly elevated production of H2O2 has been documented in the non-inflamed colonic epithelium of individuals with UC. Treatment to normalize colonic H2O2 leads to long-lasting histologic remission.
Publish Date 2022-08-16 11:59
Citation Pravda J. Evidence-based pathogenesis and treatment of ulcerative colitis: a causal role for colonic epithelial hydrogen peroxide. World J Gastroenterol 2022;28(31): 4263-4298
URL https://www.wjgnet.com/1007-9327/full/v28/i31/4263.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i31.4263
Full Article (PDF) WJG-28-4263.pdf
Full Article (Word) WJG-28-4263.docx
Manuscript File 75384_Auto_Edited-LS.docx
Answering Reviewers 75384-Answering reviewers.pdf
Audio Core Tip 75384-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 75384-Conflict-of-interest statement.pdf
Copyright License Agreement 75384-Copyright license agreement.pdf
Peer-review Report 75384-Peer-review(s).pdf
Scientific Misconduct Check 75384-Bing-Wang JJ-2.png
Scientific Editor Work List 75384-Scientific editor work list.pdf