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Articles Published Processes
6/10/2022 2:05:28 AM | Browse: 661 | Download: 1675
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Received |
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2022-01-27 12:12 |
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Peer-Review Started |
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2022-01-27 12:14 |
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First Decision by Editorial Office Director |
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2022-04-17 08:06 |
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Return for Revision |
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2022-04-17 08:06 |
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Revised |
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2022-05-04 12:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-05-20 03:08 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-05-23 00:43 |
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Articles in Press |
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2022-05-23 00:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-05-31 21:45 |
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Publish the Manuscript Online |
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2022-06-10 02:05 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Insight on BRAFV600E mutated colorectal cancer immune microenvironment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hassan Mohammed Abushukair, Sara Mu'amar Zaitoun and Anwaar Saeed |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Anwaar Saeed, MD, N/A, N/A, Department of Medicine, Division of Medical Oncology, The University of Kansas Cancer Center, 2330 Shawnee Mission Pkwy, Suite 210, Kansas City, KS 66205, United States. asaeed@kumc.edu |
| Key Words |
Colorectal cancer; BRAFV600E; Tumor microenvironment; Microsatellite instability; Macrophages; Immune checkpoint proteins |
| Core Tip |
The immune landscape of the tumor microenvironment is a crucial indicator of the proliferative and invasive activity of the tumor cells and serves as a predictor of response to targeted immunotherapeutic modalities. BRAFV600E is one of the most common driver mutations in colorectal cancer thought to have a unique impact on the tumor immune microenvironment. It is unknown whether this impact is of a suppressive or activating nature. Future studies on larger samples, considering a wider array of immune elements, such as the infiltration of relevant immune cells as well as immune checkpoints’ expression, are needed. |
| Publish Date |
2022-06-10 02:05 |
| Citation |
Abushukair HM, Zaitoun SM, Saeed A. Insight on BRAFV600E mutated colorectal cancer immune microenvironment. World J Gastrointest Oncol 2022; 14(6): 1213-1215 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i6/1213.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i6.1213 |
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