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Articles Published Processes
7/19/2022 7:32:06 AM | Browse: 450 | Download: 836
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Received |
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2022-01-31 20:32 |
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Peer-Review Started |
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2022-01-31 20:34 |
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To Make the First Decision |
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Return for Revision |
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2022-04-18 20:57 |
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Revised |
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2022-04-29 12:39 |
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Second Decision |
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2022-06-22 09:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-06-27 00:08 |
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Articles in Press |
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2022-06-27 00:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-06-08 03:42 |
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Typeset the Manuscript |
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2022-06-29 03:09 |
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Publish the Manuscript Online |
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2022-07-19 07:32 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Minireviews |
| Article Title |
Genetic variables of the glutamatergic system associated with treatment-resistant depression: A review of the literature
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Estela Saez, Leire Erkoreka, Teresa Moreno-Calle, Belen Berjano, Ana Gonzalez-Pinto, Nieves Basterreche and Aurora Arrue |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Leire Erkoreka, MD, PhD, Associate Chief Physician, Department of Psychiatry, Barrualde-Galdakao Integrated Health Organization, Osakidetza-Basque Health Service, Labeaga Auzoa 46A, Galdakao 48960, Spain. leire.erkorekagonzalez@osakidetza.eus |
| Key Words |
Genetics; N-methyl-D-aspartic acid receptor; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; Treatment-resistant depression; Ketamine; Esketamine |
| Core Tip |
Depression is a common mental disorder and one of the leading causes of disability worldwide. Up to 15%-40% of cases are considered treatment-resistant depression, which seems to be conditioned by environmental and genetic factors. The glutamatergic system and, specifically, N-methyl-D-aspartic acid receptor (NMDAR) dysfunction, has been proposed to be involved in the pathogenesis of treatment-resistant depression (TRD). A literature search was performed to identify studies on the genetics of the glutamatergic system in depression, focused on NMDAR and the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor. Our review highlights GRIN2B, which encodes the NR2B subunit of NMDAR, as a candidate gene in the pathogenesis of TRD. |
| Publish Date |
2022-07-19 07:32 |
| Citation |
Saez E, Erkoreka L, Moreno-Calle T, Berjano B, Gonzalez-Pinto A, Basterreche N, Arrue A. Genetic variables of the glutamatergic system associated with treatment-resistant depression: A review of the literature. World J Psychiatry 2022; 12(7): 884-896 |
| URL |
https://www.wjgnet.com/2220-3206/full/v12/i7/884.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v12.i7.884 |
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