Publication Name	World Journal of Biological Chemistry
Manuscript ID	7545
Country	Brazil

Received	2013-11-24 11:48
Peer-Review Started	2013-11-24 14:42
To Make the First Decision	2013-12-25 18:11
Return for Revision	2013-12-26 20:28
Revised	2014-01-07 21:48
Second Decision	2014-02-18 11:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-18 12:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-14 04:48
Typeset the Manuscript	2014-05-19 12:07
Publish the Manuscript Online	2014-06-11 10:30

ISSN	1949-8454 (online)
Open Access
Copyright
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	“Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases
Manuscript Source	Invited Manuscript
All Author List	Gabriela Vaz Meirelles, Arina Marina Perez, Edmárcia Elisa de Souza, Fernanda Luisa Basei, Priscila Ferreira Papa, Talita Diniz Melo Hanchuk, Vanessa Bomfim Cardoso and Jörg Kobarg
Funding Agency and Grant Number	Funding Agency Grant Number Fundação de Amparo à Pesquisa do Estado São Paulo (FAPESP) 2010/51730-0 Conselho Nacional de Pesquisa e Desenvolvimento (CNPq) Centro Nacional de Pesquisa em Energia e Materiais (CNPEM)
Corresponding Author	Jorg Kobarg, PhD, Laboratório Nacional de Biociências, Centro Nacional de Pesquisa em Energia e Materiais, Rua Giuseppe Máximo Scolfaro 10.000, C.P. 6192, Campinas, SP 13084-971, Brasil. jorg.kobarg@lnbio.cnpem.br
Key Words	Cell cycle; Mitosis; DNA damage response; Protein interactions; Kinases
Core Tip	Never in mitosis-gene A (NIMA)-related kinases (Neks) are a family of 11 human kinases involved in cell cycle regulation. This article represents an in-depth review of the current knowledge on the function of each of the 11 human Nek kinases. Furthermore, we present arguments in the discussion of how systems biology, especially interactomics, helped to uncover that the majority of Neks are involved in more than one of the three Neks core functions: (1) centrioles/mitosis; (2) primary ciliary function/ciliopathies; and (3) the DNA damage response. Possibly, the Neks act on a higher regulatory level which may control the core functions.
Publish Date	2014-06-11 10:30
Citation	Meirelles GV, Perez AM, de Souza EE, Basei FL, Papa PF, Melo Hanchuk TD, Cardoso VB, Kobarg J. “Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases. World J Biol Chem 2014; 5(2): 141-160
URL	http://www.wjgnet.com/1949-8454/full/v5/i2/141.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i2.141

Full Article (PDF)	wjbc-5-141.pdf
Full Article (Word)	wjbc-5-141.doc
Manuscript File	7545-Review.docx
Answering Reviewers	7545-Answering reviews.pdf
Copyright License Agreement	7545-Copyright agreement.pdf
Non-Native Speakers of English Editing Certificate	7545-Language certificate.pdf
Peer-review Report	7545-Peer reviews.pdf
Scientific Editor Work List	7545-Scientific editor work list.doc