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Articles Published Processes
5/12/2022 8:42:29 AM | Browse: 364 | Download: 715
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Received |
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2022-01-30 09:13 |
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Peer-Review Started |
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2022-01-30 09:14 |
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To Make the First Decision |
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Return for Revision |
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2022-02-24 05:46 |
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Revised |
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2022-02-28 08:05 |
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Second Decision |
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2022-03-18 06:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-03-27 05:22 |
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Articles in Press |
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2022-03-27 05:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-04-23 07:02 |
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Publish the Manuscript Online |
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2022-05-12 08:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Fusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Na Wu, Yu-Qing Feng, Na Lyu, Di Wang, Wei-Dong Yu and Yong-Fei Hu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
32070116 |
| Open Project Program of CAS Key Laboratory of Pathogenic Microbiology and Immunology |
CASPMI202102 |
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| Corresponding Author |
Yong-Fei Hu, PhD, Professor, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, China. huyongfei@cau.edu.cn |
| Key Words |
Fusobacterium nucleatum; Mucosal microbiota; Transcriptome; Colorectal cancer; Inflammation-inducing bacteria |
| Core Tip |
Fusobacterium nucleatum (F. nucleatum) has long been known to cause opportunistic infections and has recently been implicated in colorectal cancer (CRC). However, the mechanism by which it is involved in CRC development is not fully understood. Here, striking differences in mucosal microbial population patterns were observed and inflammation-inducing bacteria were enriched in the mucosal microbiota in the azoxymethane/dextran sulfate sodium salt-FUSO group. We showed that transcriptional activity was strongly affected by dysbiosis of the gut microbiota. Additionally, we showed that microbial dysbiosis driven by F. nucleatum infection enriched eight taxa belonging to Proteobacteria, which correlates with increased expression of oncogenic genes. |
| Publish Date |
2022-05-12 08:42 |
| Citation |
Wu N, Feng YQ, Lyu N, Wang D, Yu WD, Hu YF. Fusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model. World J Gastroenterol 2022; 28(18): 1981-1995 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i18/1981.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i18.1981 |
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