| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Exosomal glypican-1 is elevated in pancreatic precursors and can signal genetic predisposition in absence of endoscopic ultrasound abnormalities
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Pedro Moutinho-Ribeiro, Ines A Batista, Sofia T Quintas, Bárbara Adem, Marco Silva, Rui Morais, Armando Peixoto, Rosa Coelho, Pedro Costa-Moreira, Renato Medas, Susana Lopes, Filipe Vilas-Boas, Manuela Baptista, Diogo Dias-Silva, Ana L Esteves, Filipa Martins, Joanne Lopes, Helena Barroca, Fátima Carneiro, Guilherme Macedo and Sonia A Melo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guilherme Macedo team was supported by a Portuguese Society of Digestive Endoscopy (SPED) 2017 Research Grant |
SG/CHSJ-A2017 |
| Norte Portugal Regional Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (ERDF) to Sonia A Melo |
NORTE-01-0145-FEDER-000029 |
| National Funds through Foundation for Science and Technology (FCT) to Sonia A Melo |
POCI-01-0145-FEDER-32189 |
| Foundation for Science and Technology (FCT) to Bárbara Adem and Ines A Batista |
PD/BD/135546/2018 |
| Foundation for Science and Technology (FCT) to Bárbara Adem and Ines A Batista |
SFRH/BD/144854/2019 |
|
| Corresponding Author |
Sonia A Melo, PhD, Academic Research, Assistant Professor, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, R. Alfredo Allen 208, Porto 4200, Portugal. smelo@i3s.up.pt |
| Key Words |
Glypican-1; Circulating exosomes; Endoscopic ultrasound; Pancreatic cancer risk groups; Pancreatic cancer precursor lesions; Genetic predisposition |
| Core Tip |
Patients with mucinous cystic lesions (MCL), individuals with hereditary risk (HR) and patients with new-late onset diabetes mellitus represent a target for early pancreatic ductal adenocarcinoma (PDAC) detection. Within these groups, we evaluated the capacity of glypican-1 positive (GPC1+) circulating exosomes (crExos) to identify individuals at higher risk, all characterized by endoscopic ultrasound (EUS). High levels of GPC1+ crExos are present in MCL (increased when worrisome features or high-risk stigmata are noted) and in individuals with HR (predominantly in those with history of cancer), even in absence of EUS abnormalities. GPC1 may represent a biomarker to support the diagnosis and stratification of PDAC precursor lesions, and in signaling genetic predisposition. |
| Publish Date |
2022-08-16 11:59 |
| Citation |
Moutinho-Ribeiro P, Batista IA, Quintas ST, Adem B, Silva M, Morais R, Peixoto A, Coelho R, Costa-Moreira P, Medas R, Lopes S, Vilas-Boas F, Baptista M, Dias-Silva D, Esteves AL, Martins F, Lopes J, Barroca H, Carneiro F, Macedo G, Melo SA. Exosomal glypican-1 is elevated in pancreatic precursors and can signal genetic predisposition in absence of endoscopic ultrasound abnormalities. World J Gastroenterol 2022;28(31): 4310-4327 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i31/4310.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i31.4310 |
