Publication Name	World Journal of Hepatology
Manuscript ID	75705
Country	France

Received	2022-03-16 15:45
Peer-Review Started	2022-03-16 15:58
To Make the First Decision
Return for Revision	2022-04-28 07:37
Revised	2022-05-11 16:01
Second Decision	2022-06-24 03:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-24 22:31
Articles in Press	2022-06-24 22:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-07-22 11:42
Typeset the Manuscript	2022-08-17 07:43
Publish the Manuscript Online	2022-08-26 09:51

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemical Research Methods
Manuscript Type	Clinical Trials Study
Article Title	Iohexol plasma and urinary concentrations in cirrhotic patients: A pilot study
Manuscript Source	Unsolicited Manuscript
All Author List	Paul Carrier, Alexandre Destere, Baptiste Giguet, Marilyne Debette-Gratien, Marie Essig, Caroline Monchaud, Jean-Baptiste Woillard and Véronique Loustaud-Ratti
ORCID	Author(s) ORCID Number Paul Carrier http://orcid.org/0000-0001-9750-2506 Marilyne Debette-Gratien http://orcid.org/0000-0001-6039-1355 Marie Essig http://orcid.org/0000-0002-2030-5616 Véronique Loustaud-Ratti http://orcid.org/0000-0002-6951-0784
Funding Agency and Grant Number
Corresponding Author	Véronique Loustaud-Ratti, MD, Professor, Department of Liver Disease, Limoges University Hospital Center, U1248, INSERM, 2 avenue Martin Luther King, Limoges F-87000, France. veronique.loustaud-ratti@unilim.fr
Key Words	Cirrhosis; Glomerular filtration Rate; Iohexol; Pharmacokinetics; Brochner-Mortensen
Core Tip	Accurately evaluating the glomerular filtration rate in cirrhotic patients is critical to optimize their management and identify patients who should be prioritized for liver transplantation, and informs discussion of double liver-kidney transplantation. Until now, no formula or direct method for measuring the glomerular filtration rate was available. This prospective pilot study is the first to systematically describe the plasma and urinary concentrations of iohexol, based on the kinetics of samples collected over 24 h from cirrhotic patients with three different ascites grades. The next step will be to construct a Bayesian estimator from a limited number of samples.
Publish Date	2022-08-26 09:51
Citation	Carrier P, Destere A, Giguet B, Debette-Gratien M, Essig M, Monchaud C, Woillard JB, Loustaud-Ratti V. Iohexol plasma and urinary concentrations in cirrhotic patients: A pilot study. World J Hepatol 2022; 14(8): 1621-1632
URL	https://www.wjgnet.com/1948-5182/full/v14/i8/1621.htm
DOI	https://dx.doi.org/10.4254/wjh.v14.i8.1621

Full Article (PDF)	WJH-14-1621.pdf
Full Article (Word)	WJH-14-1621.docx
Manuscript File	75705_Auto_Edited-LM_Kerr C_Clear Copy.docx
Answering Reviewers	75705-Answering reviewers.pdf
Audio Core Tip	75705-Audio core tip.mp3
Biostatistics Review Certificate	75705-Biostatistics statement.pdf
Clinical Trial Registration Statement	75705-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	75705-Conflict-of-interest statement.pdf
Copyright License Agreement	75705-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	75705-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	75705-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	75705-Language certificate.pdf
Supplementary Material	75705-Supplementary material.pdf
Peer-review Report	75705-Peer-review(s).pdf
Scientific Misconduct Check	75705-Bing-Liu JH-2.jpg
Scientific Misconduct Check	75705-CrossCheck.jpg
Scientific Editor Work List	75705-Scientific editor work list.pdf