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Articles Published Processes
8/8/2014 5:10:00 PM | Browse: 1412 | Download: 1479
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Received |
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2013-11-25 15:30 |
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Peer-Review Started |
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2013-11-25 19:19 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-02-20 20:36 |
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Revised |
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2014-03-06 08:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-06-03 16:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-06-03 16:32 |
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Articles in Press |
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2014-06-03 16:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-08-05 18:38 |
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Publish the Manuscript Online |
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2014-08-08 17:11 |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
SH2B1 regulation of energy balance, body weight, and glucose metabolism
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Liangyou Rui |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health (NIH) |
RO1 DK 065122 |
| National Institutes of Health (NIH) |
RO1 DK091591 |
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| Corresponding Author |
Liangyou Rui, PhD, Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Ann Arbor, MI 48109, United States. ruily@umich.edu |
| Key Words |
Obesity; Type 2 diabetes; Leptin resistance; Insulin resistance; Glucose intolerance; Hypothalamus; Energy balance; Food intake; Hyperphagia; Nonalcoholic fatty liver disease |
| Core Tip |
The Src homology 2B (SH2B) family members mediate cell signaling in response to a variety of hormones, cytokines, and growth factors. In the brain, SH2B1 enhances leptin signaling and leptin’s anti-obesity action. In peripheral tissues, SH2B1 cell-autonomously enhances insulin signaling. In pancreatic islets, SH2B1 is required for compensatory ? cell expansion in response to insulin resistance and ? cell stress. SH2B1-deficiency results in severe leptin resistance, energy imbalance, obesity, and type 2 diabetes. SH2B1 mutations are linked to leptin resistance, insulin resistance, obesity, and type 2 diabetes in humans. Thus, SH2B1 is a critical metabolic regulator in mammals. |
| Publish Date |
2014-08-08 17:11 |
| Citation |
Rui L. SH2B1 regulation of energy balance, body weight, and glucose metabolism. World J Diabetes 2014; 5(4): 511-526 |
| URL |
http://www.wjgnet.com/1948-9358/full/v5/i4/511.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v5.i4.511 |
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