Publication Name	World Journal of Diabetes
Manuscript ID	7577
Country	United States

Received	2013-11-25 15:30
Peer-Review Started	2013-11-25 19:19
To Make the First Decision	2014-02-13 16:16
Return for Revision	2014-02-20 20:36
Revised	2014-03-06 08:30
Second Decision	2014-06-03 16:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-03 16:32
Articles in Press	2014-06-03 16:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-05 18:38
Publish the Manuscript Online	2014-08-08 17:11

ISSN	1948-9358 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	SH2B1 regulation of energy balance, body weight, and glucose metabolism
Manuscript Source	Invited Manuscript
All Author List	Liangyou Rui
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health (NIH) RO1 DK 065122 National Institutes of Health (NIH) RO1 DK091591
Corresponding Author	Liangyou Rui, PhD, Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, Ann Arbor, MI 48109, United States. ruily@umich.edu
Key Words	Obesity; Type 2 diabetes; Leptin resistance; Insulin resistance; Glucose intolerance; Hypothalamus; Energy balance; Food intake; Hyperphagia; Nonalcoholic fatty liver disease
Core Tip	The Src homology 2B (SH2B) family members mediate cell signaling in response to a variety of hormones, cytokines, and growth factors. In the brain, SH2B1 enhances leptin signaling and leptin’s anti-obesity action. In peripheral tissues, SH2B1 cell-autonomously enhances insulin signaling. In pancreatic islets, SH2B1 is required for compensatory ? cell expansion in response to insulin resistance and ? cell stress. SH2B1-deficiency results in severe leptin resistance, energy imbalance, obesity, and type 2 diabetes. SH2B1 mutations are linked to leptin resistance, insulin resistance, obesity, and type 2 diabetes in humans. Thus, SH2B1 is a critical metabolic regulator in mammals.
Publish Date	2014-08-08 17:11
Citation	Rui L. SH2B1 regulation of energy balance, body weight, and glucose metabolism. World J Diabetes 2014; 5(4): 511-526
URL	http://www.wjgnet.com/1948-9358/full/v5/i4/511.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i4.511

Full Article (PDF)	WJD-5-511.pdf
Full Article (Word)	WJD-5-511.doc
Manuscript File	7577-Review.docx
Answering Reviewers	7577-Answering reviewers.pdf
Copyright License Agreement	7577-Copyright assignment.pdf
Peer-review Report	7577-Peer review(s).pdf
Scientific Misconduct Check	7577-CrossCheck.jpg
Scientific Editor Work List	7577-Scientific editor work list.pdf