Publication Name	World Journal of Gastroenterology
Manuscript ID	75806
Country	Togo

Received	2022-02-16 03:40
Peer-Review Started	2022-02-16 03:44
To Make the First Decision
Return for Revision	2022-04-12 01:06
Revised	2022-04-24 07:55
Second Decision	2022-06-21 03:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-26 06:34
Articles in Press	2022-06-26 06:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-14 06:33
Publish the Manuscript Online	2022-07-27 02:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Potassium-competitive acid blockers and gastroesophageal reflux disease
Manuscript Source	Invited Manuscript
All Author List	Wattana Leowattana and Tawithep Leowattana
ORCID	Author(s) ORCID Number Wattana Leowattana http://orcid.org/0000-0003-4257-2480 Tawithep Leowattana http://orcid.org/0000-0003-2316-3585
Funding Agency and Grant Number
Corresponding Author	Wattana Leowattana, MD, MSc, PhD, Professor, Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajavithi Road, Rachatawee, Bangkok 10400, Thailand. wattana.leo@mahidol.ac.th
Key Words	Potassium-competitive acid blocker; Gastroesophageal reflux disease; Proton pump inhibitors; Treatment outcome; Proton pump inhibitor-refractory patients; Esophageal mucosal resistance
Core Tip	The potassium-competitive acid blocker (P-CAB) has been discovered as a possible acid suppression therapeutic option. At the enzyme level, P-CABs compete with K+ to suppress acid formation; the binding location of these compounds is separate from the probable pocket that K+ occupies. When the P-CAB binds to the enzyme, it stops K+ from attaching and activating it. According to clinical trials, P-CABs are extremely selective for gastric H+, K+-ATPase, restricting stomach acid production while acting quickly. Such medicines, which can have a rapid onset of action and a longer duration, may offer considerable advantages to individuals suffering from gastroesophageal reflux disease and other acid-related disorders.
Publish Date	2022-07-27 02:48
Citation	Leowattana W, Leowattana T. Potassium-competitive acid blockers and gastroesophageal reflux disease. World J Gastroenterol 2022; 28(28): 3608-3619
URL	https://www.wjgnet.com/1007-9327/full/v28/i28/3608.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i28.3608

Full Article (PDF)	WJG-28-3608.pdf
Full Article (Word)	WJG-28-3608.docx
Manuscript File	75806_Auto_Edited-LS.docx
Answering Reviewers	75806-Answering reviewers.pdf
Audio Core Tip	75806-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	75806-Conflict-of-interest statement.pdf
Copyright License Agreement	75806-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	75806-Language certificate.pdf
Peer-review Report	75806-Peer-review(s).pdf
Scientific Misconduct Check	75806-Bing-Fan JR-2.png
Scientific Editor Work List	75806-Scientific editor work list.pdf