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Articles Published Processes
7/27/2022 2:48:53 AM | Browse: 522 | Download: 1375
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Received |
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2022-02-16 03:40 |
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Peer-Review Started |
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2022-02-16 03:44 |
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First Decision by Editorial Office Director |
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2022-04-12 01:06 |
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Return for Revision |
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2022-04-12 01:06 |
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Revised |
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2022-04-24 07:55 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-06-21 03:08 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-06-26 06:34 |
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Articles in Press |
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2022-06-26 06:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-14 06:33 |
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Publish the Manuscript Online |
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2022-07-27 02:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Potassium-competitive acid blockers and gastroesophageal reflux disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wattana Leowattana and Tawithep Leowattana |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wattana Leowattana, MD, MSc, PhD, Professor, Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajavithi Road, Rachatawee, Bangkok 10400, Thailand. wattana.leo@mahidol.ac.th |
| Key Words |
Potassium-competitive acid blocker; Gastroesophageal reflux disease; Proton pump inhibitors; Treatment outcome; Proton pump inhibitor-refractory patients; Esophageal mucosal resistance |
| Core Tip |
The potassium-competitive acid blocker (P-CAB) has been discovered as a possible acid suppression therapeutic option. At the enzyme level, P-CABs compete with K+ to suppress acid formation; the binding location of these compounds is separate from the probable pocket that K+ occupies. When the P-CAB binds to the enzyme, it stops K+ from attaching and activating it. According to clinical trials, P-CABs are extremely selective for gastric H+, K+-ATPase, restricting stomach acid production while acting quickly. Such medicines, which can have a rapid onset of action and a longer duration, may offer considerable advantages to individuals suffering from gastroesophageal reflux disease and other acid-related disorders. |
| Publish Date |
2022-07-27 02:48 |
| Citation |
Leowattana W, Leowattana T. Potassium-competitive acid blockers and gastroesophageal reflux disease. World J Gastroenterol 2022; 28(28): 3608-3619 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i28/3608.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i28.3608 |
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